Involvement of ABCA1 transporter in the regulation of anti-atherogenic sphingosine-1-phosphate content in plasma and high-density lipoprotein
Involvement of ABCA1 transporter in the regulation of anti-atherogenic sphingosine-1-phosphate content in plasma and high-density lipoprotein
批准号:
21591158
负责人:
SATO Koichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Sphingosine 1-phosphate (S1P) is accumulated in plasma high-density lipoprotein (HDL), which induces anti-atherogenic actions in endothelial and smooth muscle cells. However, it remains uncharacterized how extracellular S1P is produced and accumulated in HDL particles. This study has focused on the relationship between S1P accumulation in HDL particles and lipoprotein formation by ATP-binding cassette transporter A1 (ABCA1 transporter). Our results using ABCA1 transporter-deficient and lecithin-cholesterol acyltransferase-deficient mice suggested that ABCA1 transporter may be involved in the accumulation of S1P in HDL particles.
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ラットアストロサイトにおけるインターロイキンー1βによるリゾホスファチジン酸受容体/遊走応答系の特異的な増強作用とRhoシグナリング
IL-1β对大鼠星形胶质细胞中溶血磷脂酸受体/迁移反应系统和 Rho 信号传导的特异性增强
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[佐藤幸市, 堀内雄太, 小町麻由美, 岡島史和]
通讯作者:
岡島史和
β-adrenergic agonist, isoproterenol, inhibits lysophosphatidic acid-induced glioma cell migration through the cAMP/Epac/Rap1B/PTEN-dependent signaling pathways
β-肾上腺素能激动剂异丙肾上腺素通过 cAMP/Epac/Rap1B/PTEN 依赖性信号通路抑制溶血磷脂酸诱导的神经胶质瘤细胞迁移
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Koichi Sato, Enkhzol Malchinkhuu, Fumikazu Okajima]
通讯作者:
Fumikazu Okajima
Extracellular acidification simulates IL-6 production and Ca^<2+> mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells.
细胞外酸化通过人气道平滑肌细胞中的质子感应OGR1受体模拟IL-6产生和Ca 2+ 动员。
DOI:
--
发表时间:
2010
期刊:
Am.J.Physiol.Lung Cell.Mol.Physiol.
影响因子:
--
作者:
[田中佑佳、阪上浩, ほか, Isao Ichimonji]
通讯作者:
Isao Ichimonji
リポタンパク質作用におけるS1Pの役割とそのシグナル伝達機構
S1P在脂蛋白作用中的作用及其信号转导机制
DOI:
--
发表时间:
2009
期刊:
生化学
影响因子:
--
作者:
[岡島史和, 木村孝穂, 佐藤幸市]
通讯作者:
佐藤幸市
ラットアストロサイトにおけるインターロイキンー1βによるリゾホスファチジン酸受容体/遊走応答系の特異のな増強作用とRhoシグナリング
大鼠星形胶质细胞中白细胞介素 1β 对溶血磷脂酸受体/迁移反应系统和 Rho 信号传导的独特增强
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L.Fitzgerald, Shinji Yokoyama, 佐藤幸市]
通讯作者:
佐藤幸市
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Changes in properties of watershed and its conservation due to changes in land use in mountainous rural area
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