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Identification and functional analysis of novel bioactive peptides associated with feeding regulation and lifestyle-related disease

Identification and functional analysis of novel bioactive peptides associated with feeding regulation and lifestyle-related disease
与摄食调节和生活方式相关疾病相关的新型生物活性肽的鉴定和功能分析
批准号：
21591189
负责人：
MIYAZATO Mikiya
金额：
$2.91万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591189/
关键词：
ペプチド摂食調節生活習慣病オーファン受容体

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中文摘要
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英文摘要
To search for novel bioactive peptides associated with feeding regulation and lifestyle-related diseases, we used the orphan receptor strategy and newly established methods to find some candidates as novel bioactive substances. By using gene deficient mice of ghrelin or neuromed in S(NMS), we demonstrated that endogenous ghrelin suppresses sympathetic nerve activity and improves the prognosis after acute myocardial infarction, and that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system.
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会议论文
Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds
DOI： 10.1016/j.ygcen.2008.11.008
发表时间： 2009-08-01
期刊： GENERAL AND COMPARATIVE ENDOCRINOLOGY
影响因子： 2.7
作者： [Kaiya, Hiroyuki, Furuse, Mitsuhiro, Kangawa, Kenji]
通讯作者： Kangawa, Kenji
Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats.
DOI： 10.1677/joe-10-0081
发表时间： 2010-11
期刊： The Journal of endocrinology
影响因子： --
作者： [K. Nakahara;T. Katayama;K. Maruyama;T. Ida;K. Mori;M. Miyazato;K. Kangawa;N. Murakami]
通讯作者： K. Nakahara;T. Katayama;K. Maruyama;T. Ida;K. Mori;M. Miyazato;K. Kangawa;N. Murakami
Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides
DOI： 10.1161/atvbaha.109.187526
发表时间： 2009-10-01
期刊： ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子： 8.7
作者： [Tokudome, Takeshi, Kishimoto, Ichiro, Kangawa, Kenji]
通讯作者： Kangawa, Kenji
Ghrelin receptor(GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss
虹鳟鱼生长素释放肽受体（GHS-R）样受体及其基因组结构
DOI： 10.1016/j.cbpa.2009.04.612
发表时间： 2009
期刊： Comp Biochem Physiol A Mol Integr Physiol
影响因子： --
作者： [Kaiya H, Mori T, Miyazato M, Kangawa K]
通讯作者： Kangawa K
共 21 条
    Investigation of cardiovascular regulation and multiple function of gastrointestinal peptides
    Investigation of cardiovascular regulation based on the association with autonomic nerve and brain-gut peptides
    Elucidation of new biological regulatory mechanism with fatty acid-modified peptide family and receptors
    Search and functional analysis for novel bioactive peptides related with lifestyle-related disease
    海外基金