Analysis of single nucleotide polymorphisms of glycosyltransferase gene responsible for the biosysnthesis of gastricο-glycans and its significance for genetic factor involved in the development of gastric diseases

末端为α1，4-N-乙酰葡糖胺（αGlcNAc）的α-聚糖是胃腺粘液细胞型粘蛋白所特有的，α1，4-N-乙酰葡糖胺转移酶（α4GnT）是负责该聚糖生物合成的关键酶。通过对H. pylori感染的胃炎/胃溃疡和胃癌以及αGlcNAc缺陷的突变小鼠，我们分别揭示了A4 GNT基因的单核苷酸多态性（rs 22469459）可能是胃癌分化型腺癌的独立危险因素，而αGlcNAc可能通过抑制促癌性慢性炎症而预防胃癌

ο-glycans having terminalα1, 4-linked N-acetylglucosamine(αGlcNAc) are unique to the gastric gland mucous cell-type mucin, andα1, 4-N-acetylglucosaminyltranseferase(α4GnT) is the key enzyme responsible for the biosynthesis of the glycans. By analyzing the genome DNA prepared from the patients with H. pylori infected gastritis/gastric ulcer and gastric cancer, and the mutant mice deficient inαGlcNAc, we revealed that the single nucleotide polymorphism of A4GNT gene(rs22469459) could be an independent risk factor for gastric differentiated-type adenocarcinoma, and thatαGlcNAc prevents gastric cancer by suppressing tumor-promoting chronic inflammation, respectively