Analysis of single nucleotide polymorphisms of glycosyltransferase gene responsible for the biosysnthesis of gastricο-glycans and its significance for genetic factor involved in the development of gastric diseases

胃聚糖生物合成糖基转移酶基因单核苷酸多态性分析及其对胃病发生遗传因素的意义

• 批准号: 21390104
• 负责人: NAKAYAMA Jun
• 金额: $ 11.9万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390104/
• 关键词: 糖転移酵素; 糖鎖遺伝子; 一塩基遺伝子多型; ピロリ菌; 慢性胃炎; ノックアウトマウス; 胃粘膜; 慢性炎症; 胃癌; 1塩基遺伝子多型

ο-glycans having terminalα1, 4-linked N-acetylglucosamine(αGlcNAc) are unique to the gastric gland mucous cell-type mucin, andα1, 4-N-acetylglucosaminyltranseferase(α4GnT) is the key enzyme responsible for the biosynthesis of the glycans. By analyzing the genome DNA prepared from the patients with H. pylori infected gastritis/gastric ulcer and gastric cancer, and the mutant mice deficient inαGlcNAc, we revealed that the single nucleotide polymorphism of A4GNT gene(rs22469459) could be an independent risk factor for gastric differentiated-type adenocarcinoma, and thatαGlcNAc prevents gastric cancer by suppressing tumor-promoting chronic inflammation, respectively

末端为α1，4-N-乙酰葡糖胺（αGlcNAc）的α-聚糖是胃腺粘液细胞型粘蛋白所特有的，α1，4-N-乙酰葡糖胺转移酶（α4GnT）是负责该聚糖生物合成的关键酶。通过对H. pylori感染的胃炎/胃溃疡和胃癌以及αGlcNAc缺陷的突变小鼠，我们分别揭示了A4 GNT基因的单核苷酸多态性（rs 22469459）可能是胃癌分化型腺癌的独立危险因素，而αGlcNAc可能通过抑制促癌性慢性炎症而预防胃癌

项目成果

Delineation of Dermatan 4-O-sulfotransferase 1 Deficient Ehlers-Danlos Syndrome: Observation of Two Additional Patients and Comprehensive Review of 20 Reported Patients

• DOI: 10.1002/ajmg.a.34115
• 发表时间: 2011-08-01
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART A
• 影响因子: 2
• 作者: Shimizu, Kenji;Okamoto, Nobuhiko;Kosho, Tomoki
• 通讯作者: Kosho, Tomoki

防御因子としての胃腺粘液糖鎖の役割

胃粘液糖链作为保护因子的作用

• 发表时间: 2011
• 作者: Yatsuya H;Toyoshima H;Yamagishi K;Tamakoshi K;Taguri M;Harada A;Ohashi Y;Kita Y;Naito Y;Yamada M;Tanabe N;Iso H;Ueshima H;中山淳
• 通讯作者: 中山淳

胃腺粘液の機能-糖鎖研究からのアプローチ

胃腺粘液的功能 - 来自聚糖研究的方法

• 发表时间: 2011
• 作者: 石合正道;島弘季;田代聡;高田穣;中山淳
• 通讯作者: 中山淳

糖鎖研究の新展開

聚糖研究新进展

• 发表时间: 2010
• 作者: Toyoda;et al.;中山淳
• 通讯作者: 中山淳

USEFULNESS OF DOUBLE BALLOON ENTEROSCOPY AND VIDEO CAPSULE ENDOSCOPY FOR THE DIAGNOSIS AND MANAGEMENT OF PRIMARY FOLLICULAR LYMPHOMA OF THE GASTROINTESTINAL TRACT IN ITS EARLY STAGES

• DOI: 10.1111/j.1443-1661.2009.00915.x
• 发表时间: 2010-01-01
• 期刊: DIGESTIVE ENDOSCOPY
• 影响因子: 5.3
• 作者: Akamatsu, Taiji;Kaneko, Yasunori;Tanaka, Eiji
• 通讯作者: Tanaka, Eiji