Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer By Gene expression Analysis

通过基因表达分析预测直肠癌术前放化疗的反应

• 批准号: 21390383
• 负责人: WATANABE Toshiaki
• 金额: $ 10.4万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390383/
• 关键词: 直腸癌; DNAマイクロアレイ; 照射効果; 遺伝子発現; 化学放射線療法

Based on the gene expression of rectal cancer, we aimed to build a predictive model for response to chemoradiotherapy. Using 46 samples as a training set, we examined gene expression by microarray and RT-PCR. We finally selected 4 genes that were used for predictive model. The accuracy rate of prediction was 89.1% among a training set. In an independent test set of 16 samples, we validated the accuracy of a predictive model and the accuracy rate of the predictive model was 81.3%.

基于直肠癌的基因表达，我们的目的是建立一个预测模型的化疗和放疗的反应。使用46个样本作为训练集，我们通过微阵列和RT-PCR检测基因表达。我们最终选择了4个基因用于预测模型。训练集的预测准确率为89.1%。在16个样本的独立测试集中，我们验证了预测模型的准确性，预测模型的准确率为81.3%。

项目成果

Predicting Ulcerative Colitis-Associated Colorectal Cancer Using Reverse-Transcription Polymerase Chain Reaction Analysis

• DOI: 10.1016/j.clcc.2011.03.011
• 发表时间: 2011-06-01
• 期刊: CLINICAL COLORECTAL CANCER
• 影响因子: 3.4
• 作者: Watanabe, Toshiaki;Kobunai, Takashi;Nagawa, Hirokazu
• 通讯作者: Nagawa, Hirokazu

Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis

染色体 18q 缺失作为结直肠癌并发肝转移的新型分子预测因子

• 期刊: Diagn Mol Pathol (in press)
• 作者: Tanaka T;Watanabe T;Kitayama J;Kazama Y;Tanaka J;Kanazawa T;Kazama S;Nagawa H.
• 通讯作者: Nagawa H.

RUNX3 copy number predicts the development of UC-associated colorectal cancer.

• DOI: 10.3892/ijo_00000839
• 发表时间: 2010-11
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Toshiaki Watanabe;T. Kobunai;H. Ikeuchi;Yoko Yamamoto;K. Matsuda;S. Ishihara;K. Nozawa;H. Iinuma;T. Kanazawa;Toshiaki Tanaka;T. Yokoyama;T. Konishi;K. Eshima;Y. Ajioka;T. Hibi;Mamoru Watanabe;T. Muto;H. Nagawa

Prognostic Value of Peritoneal Cytology and the Combination of Peritoneal Cytology and Peritoneal Dissemination in Colorectal Cancer

• DOI: 10.1007/dcr.0b013e3181b4c46e
• 发表时间: 2009-12-01
• 期刊: DISEASES OF THE COLON & RECTUM
• 影响因子: 3.9
• 作者: Nishikawa, Takeshi;Watanabe, Toshiaki;Nagawa, Hirokazu
• 通讯作者: Nagawa, Hirokazu

Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signaling pathways

有和没有 KRAS 突变的结直肠癌之间的差异基因表达特征：KRAS 通路与其他信号通路之间的串扰

• 发表时间: 2011
• 期刊: European Journal of Cancer
• 影响因子: 8.4
• 作者: Watanabe T;Kobunai T;Yamamoto Y;Matsuda K;Ishihara S;Nozawa K;Iinuma H;Ikeuchi H;Eshima K
• 通讯作者: Eshima K