Establishment of the method for oral tissue construction using gap junctional communication.

gja 1调控牙上皮成釉蛋白的表达。我们已经报道了TGF-β1诱导的ERK 1/2磷酸化通过缝隙连接通讯调节成釉蛋白的表达，本研究结果表明缝隙连接通讯调节细胞内信号。这些调控机制对于理解缝隙连接通讯在牙齿形态发生中的作用以及在其他器官形态发生中的作用具有重要意义。

Gja1 regulates ameloblastin expression in dental epithelium. We have reported that ERK1/2 phosphorylation induced by TGF-β1 regulates expression of ameloblastin via gap junctional intercellular communication.The results of this study indicated that gap junctional communication regulates intracellular signaling. And these regulatory mechanisms are important to understand the role of gap junctional comunication not only in tooth morphogenesis but also in another organs morphogenesis.