Development of prevention methods for hepatitis C - related liver tumor focusing function of nuclear receptor PPAR

在丙型肝炎病毒相关性肝肿瘤的临床表现中，核受体PPAR的激活起着重要的作用。在本研究中，利用表达丙型肝炎病毒核心蛋白的转基因小鼠，通过PPAR拮抗剂(MK886)等手段进行了几次预防肝肿瘤的尝试。大剂量MK886(40 mg/kg/d)可完全预防小鼠肝肿瘤的发生，但MK886对部分小鼠有致命性毒性。

Presentation of hepatitis C virus - related liver tumor was found that activation of nuclear receptor: PPAR exerts as an essential factor. In this study, several attempts to prevent occurrence of liver tumor by means of PPAR antagonist (MK886) etc. were done, using transgenic mice expressing hepatitis C virus core protein. Administration of high dose MK886 (40 mg/kg/day) was confirmed to completely prevent occurrence of liver tumor, however, MK886 could cause fatal toxicity in some mice.