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Cellular role and regulatory mechanism for a novel deubiquitinating enzyme in the endoplasmic reticulum

Cellular role and regulatory mechanism for a novel deubiquitinating enzyme in the endoplasmic reticulum
内质网新型去泛素化酶的细胞作用和调控机制
批准号:
22770123
负责人:
NAKAMURA Nobuhiro
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
This study has demonstrated that 1) USP19, a transmembrane deubiquitinating enzyme in the endoplasmic reticulum(ER), deubiquitinates not only typical substrates of ER-associated degradation(ERAD), but also ERAD ubiquitinating enzymes, and 2) the enzymatic activity of USP19 is dependent on the domain structures and processing of USP19. These results provide better understand of the molecular mechanism for the regulation of the ERAD pathway as well as the USP19 activity.
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DOI: 10.3389/fphys.2010.00129
发表时间: 2010-01-01
期刊: FRONTIERS IN PHYSIOLOGY
影响因子: 4
作者: [Saito, Kaori, Nakamura, Nobuhiro, Hirose, Shigehisa]
通讯作者: Hirose, Shigehisa
Regulation of expression of TEB4 (MARCH6) ubiquitin ligase by USP19 deubiquitinating enzyme
USP19 去泛素化酶对 TEB4 (MARCH6) 泛素连接酶表达的调节
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nakamura, N., Hirose, S.]
通讯作者: S.
DOI: 10.3390/membranes1040354
发表时间: 2011-12-09
期刊: Membranes
影响因子: 4.2
作者: [Nakamura N]
通讯作者: Nakamura N
Membrane-associated RING-CH 10(MARCH10) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella
膜相关 RING-CH 10(MARCH10) 是精子鞭毛的微管相关 E3 泛素连接酶
DOI: --
发表时间: 2011
期刊: J. Biol. Chem
影响因子: --
作者: [Iyengar, P. V., Hirota, T., Hirose, S., & Nakamura, N.]
通讯作者: N.
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