Myocardial protection by induced stress protein: the multilateral strategy for cardioprotection
Myocardial protection by induced stress protein: the multilateral strategy for cardioprotection
批准号:
23592994
负责人:
KITAHATA Hiroshi
金额:
$3.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
An anti-ulcer drug, geranylgeranylacetone (GGA), can protect the heart against ischemia/reperfusion injury by inducing heat shock protein. The purpose of this study was to determine whether integral membrane proteins, caveolins (Cav) are essential for GGA-induced myocardial protection and to evaluate the interaction between cardioprotection by GGA and anesthetic pre-/postconditioning.The results of experiments with wild-type and Cav-3 knockout mice have proved that GGA-iduced cardioprotection is dependent on Cav-3 expression. There was no interaction between the myocardial protection with GGA and opioid pre- and postconditioning in our experimental setting using cultured neonatal rat ventricular myocytes.
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Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate- sensitive potassium channels
可乐定抑制血管三磷酸腺苷敏感钾通道的分子机制
DOI:
--
发表时间:
2011
期刊:
Anesth Analg
影响因子:
5.7
作者:
[Kawahito S, Kawano T, Kitahata H, Oto J, Takahashi A, Takaishi K, Harada N, Nakagawa T, Kinoshita H, Azma T, Nakaya Y, Oshita S]
通讯作者:
Oshita S
Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science.
与线粒体相关的麻醉心脏保护:基础科学。
DOI:
10.2174/1381612820666140204110101
发表时间:
2014
期刊:
Current Pharmaceutical Design
影响因子:
3.1
作者:
[Mio Y, Uezono S, Kitahata H]
通讯作者:
Kitahata H
Geranylgeranylacetone induced delayed cardiac preconditioning requires caveolin-3.
香叶基香叶基丙酮诱导的延迟心脏预处理需要 Caveolin-3。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tsutsumi YM]
通讯作者:
Tsutsumi YM
Protective effects of amino acids on the ischemic myocardium via mTOR/S6 kinase pathway.
氨基酸通过 mTOR/S6 激酶途径对缺血心肌的保护作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsutsumi YM, et al.]
通讯作者:
et al.
心筋保護作用における吸入麻酔薬とゲラニルゲラニルアセトンの相互作用―細胞膜マイクロドメインに及ぼす影響―
吸入麻醉药与香叶基香叶基丙酮的相互作用对心肌的保护作用 - 对细胞膜微区的影响 -
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Nogami S, Takahashi T, Kaneuji T, Yoshiga D, Yamauchi K, 堤保夫,田中克哉,神邊紀子,曽我朋宏,北畑洋,大下修造]
通讯作者:
堤保夫,田中克哉,神邊紀子,曽我朋宏,北畑洋,大下修造
共 13 条
Myocardial protection via mTOR - Proposal of novel therapy for ischemia-reperfusion injury
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批准号:17K11909
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2017
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负责人:KITAHATA Hiroshi
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依托单位:
Role of sirtuin in volatile anesthetic-induced cardiac protection.
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批准号:26463071
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2014
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负责人:KITAHATA Hiroshi
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依托单位:
The establishment of strategy for perioperative myocardial protection by intraoperative ultra-short-acting β1 bloctker
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批准号:18591707
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.52万
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财政年份:2006
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负责人:KITAHATA Hiroshi
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依托单位:
The influence of anesthetics on cardioprotection by stress-induced protein
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批准号:13671587
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:KITAHATA Hiroshi
-
依托单位:
The influence of anesthetics on myocardial tissue ultrastructural integrity after ischemic preconditioning.
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批准号:11671502
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:1999
-
负责人:KITAHATA Hiroshi
-
依托单位:
海外基金