Establishment of model mice of systemic inflammatory response syndrome associated with multiple organ dysfunction syndrome, and investigation of associated with multiple organ dysfunction syndrome, and investigation of

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To put the molecular mechanism for pathogenesis of systemicinflammatory response syndrome (SIRS) to practical use, the following studies wereperformed. (1) Focusing on p38 which plays a central role in various inflammatoryresponses, one of mitogen-activated protein kinase (MAPK), we tried to produce transgenicmice exhibiting systemic p38 activation in a tetracycline-dependent manner. (2) Weproduced a new model mouse of sepsis in place of the cecal ligation and puncture, oneof SIRS models. Then, we investigated its reliability.