The role of GPCR signaling in the progression of gynecological cancer

GEP癌基因是异源三聚体G蛋白的Ga 12家族（Ga 12/13）的成员，参与包括乳腺癌和前列腺癌在内的人类癌症的进展。本研究旨在探讨GEP癌基因在人类妇科肿瘤进展中的作用，发现Ga 12/13在人类卵巢癌组织中的表达水平高于正常卵巢组织。在人宫颈癌细胞系中，SDF-1/CXCR 4/Gai/Rac信号通路的激活在体外诱导迁移。此外，SDF-1/CXCR 4/Gai信号通路通过p38激活上调VEGF-C表达。GEP癌基因Ga 12/13的表达增加可导致CXCR 4下游信号增强，从而影响卵巢癌细胞的迁移。

The GEP oncogene, members of the Ga12 family of heterotrimeric G proteins (Ga12/13), is involved in the progression of human cancers including breast and prostate. This study is focused on evaluating the role of GEP oncogene in human gynecological cancer progression.Expression levels of Ga12/13 in human ovarian cancer tissues were elevated compared to those in normal ovarian tissues. In human cervical cancer cell lines, activation of SDF-1/CXCR4/Gai/Rac signaling pathway induced migration in vitro. In addition, SDF-1/CXCR4/Gai signaling pathway upregulated VEGF-C expression through p38 activation. Increased expression of GEP oncogene, Ga12/13, can result in enhanced signaling downstream of CXCR4, thereby influencing cell migration of ovarian cancer.