Studies of physiological action of neurohypophyseal hormone
Studies of physiological action of neurohypophyseal hormone
批准号:
09660318
负责人:
SAITO Noboru
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
精氨酸催产素(AVT)是鸟类的神经垂体激素之一。众所周知,AVT具有抗利尿作用,并在高渗刺激下释放,但有关AVT释放机制的信息很少。本研究的目的是探讨AVT的释放机制,并比较鸟类和哺乳动物之间的机制。当鸡接受高渗盐水时,血浆AVT水平显着升高。当鸡同时给予高渗盐水和阿片肽、吗啡时,血浆AVT水平的升高受到抑制。另一方面,当鸡同时给予高渗盐水和阿片肽拮抗剂纳洛酮时,血浆AVT水平的升高进一步增强。从这些结果中,我们可以表明阿片肽可能通过高渗刺激来调节 AVT 释放。然而,排卵时AVT的释放不受阿片拮抗剂或激动剂的影响。脑室内注射AVT反义寡核苷酸可抑制高渗刺激引起的血浆AVT水平的升高。小脑内注射 AVT 有义或随机寡核苷酸不会抑制高渗刺激引起的血浆 AVT 水平的增加。反义寡核苷酸可以抑制 AVT 合成机制中 AVT mRNA 翻译成氨基酸。因此,这些数据可能支持AVT生物合成机制涉及AVT从神经垂体释放的机制。此外,这些数据表明反义寡核苷酸是研究鸟类神经内分泌学的有用工具。
英文摘要
Arginine vasotocin (AVT) is one of neurohypophyseal hormone in the birds. It is well known that AVT has an antidiuretic action and is released by hypertonic stimulation, but it is little information about the release mechanism of AVT.The aim of this study investigates the release mechanisms of AVT and compares the mechanism between birds and mammals.When the chickens were received hypertonic saline, the plasma levels of AVT significantly increased. When chickens were received simultaneously with hypertonic saline and opioid peptide, morphine, the increase of plasma levels of AVT was inhibited. On the other hands, when the chickens were received simultaneously with hypertonic saline and opioid peptide antagonist, naloxone, the increase of plasma levels of AVT was further enhanced. From these results, we can suggest that opioid peptide may regulate AVT release by hypertonic stimulation. However, AVT release at oviposiiton were not effected by opioid antagonist or agonist.The intracerebroventricular injection of AVT antisense oligonucleotide inhibited the increase of plasma levels of AVT by hypertonic stimulation. The intracerevelo injection of AVT sense or random oligonucleotide did not inhibit the increase of plasma levels of AVT by hypertonic stimulation. Antisense oligonucleotide may inhibit translation to amino acid from AVT mRNA within the AVT synthesis mechanism. Therefore, these data may support that AVT biosynthesis mechanism involves the mechanism of AVT release from the neurohypophysis. Also, these data suggest that antisense oligonucleotide is useful tool for the study of neuroendocrinology in birds.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Zhang C.: "Expression of messenger ribonucleic acids of luteinizing hormone and follicle stimulating hormone receptors in granulosa and theca layrs of chicken preovulatory follicles." Gen.Comp.Endocrinol.105. 402-409 (1997)
张春:“鸡排卵前卵泡颗粒层和卵泡膜层中促黄体生成素和卵泡刺激素受体的信使核糖核酸的表达。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Furuse M.: "Effects of crude medium chain triacylglycerol on energy utilization in growing chicks." Japanese Poultry Science. 34. 248-254 (1997)
Furuse M.:“粗制中链三酰甘油对生长中雏鸡能量利用的影响。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Furuse M.: "Influence of fasting and neuropeptide Y on the suppressive food intake induced intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick." Brain Research. 764. 289-292 (1997)
Furuse M.:“禁食和神经肽 Y 对抑制食物摄入诱导的新生小鸡脑室内注射胰高血糖素样肽-1 的影响。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Furuse M,: "Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food intake in the neonatal chick." Brain Res.807. 214-217 (1998)
Furuse M,:“胰高血糖素样肽 1(7-36) 的各种 N 末端片段对新生小鸡食物摄入的影响。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Mabayo R.T.: "Cholinergic factors are not involved in the delayed diet passage from the crop of chicks given medium chain triacylglycerols." Comparative Biochemistry and Physiology. 116A. 89-92 (1997)
Mabayo R.T.:“胆碱能因子与给予中链三酰甘油的雏鸡的饲料传递延迟无关。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 57 条
Academic Investigation Research on Strategy of Founding Graduate School of Teacher Training College to Promote Self-sustaining Improvements in Developing Country
-
批准号:15H05203
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.57万
-
财政年份:2015
-
负责人:SAITO Noboru
-
依托单位:
Development of Mathematics Teaching Model to Produce Mathematical Innovation and Application in Teacher Education
-
批准号:15K04457
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2015
-
负责人:SAITO Noboru
-
依托单位:
Academic Investigation Research for Establishing a Graduate School of Teacher Training College in Developing Country
-
批准号:23252013
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$14.81万
-
财政年份:2011
-
负责人:SAITO Noboru
-
依托单位:
Study of regulation of anti-diuretic hormone gene expression
-
批准号:23580388
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:SAITO Noboru
-
依托单位:
Academic Investigation Research for Establishing a Graduate School of University of Education in Developing Country
-
批准号:20402067
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.07万
-
财政年份:2008
-
负责人:SAITO Noboru
-
依托单位:
Study of Academic Investigation for Establishing Graduate School of University of Education in a Developing Country
-
批准号:18402044
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.3万
-
财政年份:2006
-
负责人:SAITO Noboru
-
依托单位:
The Development of Teacher Training Core Curriculum of Mathematics in University of Education
-
批准号:16500555
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2004
-
负责人:SAITO Noboru
-
依托单位:
The study of molecular marker expression in evaluation for the malignancy potential of colorectal cancer
-
批准号:16591357
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.02万
-
财政年份:2004
-
负责人:SAITO Noboru
-
依托单位:
Study of osmoregulation in birds
-
批准号:14360165
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.47万
-
财政年份:2002
-
负责人:SAITO Noboru
-
依托单位:
Osmoreceptorand arugihine vasotocin I n chicken
-
批准号:12660253
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2000
-
负责人:SAITO Noboru
-
依托单位:
RELATION AMONG THE STRUCTURAL THINKING, THE CREATIVE POWER AND POWER OF EXPRESSION
-
批准号:10680188
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1998
-
负责人:SAITO Noboru
-
依托单位:
国内基金
海外基金
基于RIA分析框架下的中国食品安全监管体系评估及优化研究
-
批准号:71573264
-
项目类别:面上项目
-
资助金额:43.0万元
-
批准年份:2015
-
负责人:刘鹏
-
依托单位: