Distribution of race-specific null alleles of the FUT2 in Africa, European and Asian populations.

ABO （H）抗原在保密中的表达，如saliva是由秘书基因（FUT 2）-编码α （1， 2） fucosyltransferase （Se enzyme）调节的。ABO秘书小组至少有一个功能性的Se Allele，而非Secretors，谁未能在Saliva中表达ABH抗原，对非功能性的Se Allele都是一致的。我们对各种人口中FUT 2的分子分析提出了一项建议，即无迹象是特定的。null allele se D1428 D1 was found to be common in African （Xhosa） and Caucasians （European and Iranian）， while the null allele D1357，385 D1 was found to be common in Asian populations （Chinese、Korean、Japanese、Indonesian an Samoan）。Frequency of se D1428，D1 and of se D1375，385，D1 in each population was 0.4 ~ 0.5。However， we found both se D1428 y D1 and se D1375，385 y D1 in a Bangrad？population。The presence of both seイD1428エD1 （0. 234） and seイD1375，385エD1 （0. 074） suggests the admixture of Aryans and Asians in Bangrad\。In addition， we found se D1 fus D1 as one of null alleles in Japanese （0.05 ~ 0.08） and the absence of the se D1 fus D1 in Chinese， suggesting that the se D1 fuus D1 emerged from within Japanese。

The expression of ABO (H) antigens in secretions such as saliva is regulated by the Secretor gene (FUT2)-encoded α (1, 2) fucosyltransferase (Se enzyme). The ABO secretor group has at least one functional Se allele, and nonsecretors, who fail to express ABH antigens in saliva, are homozygous for the nonfunctional se allele. Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific. The null allele seィイD1428ィエD1 was found to be common in African (Xhosa) and Caucasians (European and Iranian), while the null allele seィイD1357,385ィエD1 was found to be common in Asian populations (Chinese, Korean, Japanese, Indonesian an Samoan). Frequency of seィイD1428ィエD1 and of seィイD1375,385ィエD1 in each population was 0.4〜0.5. However, we found both seィイD1428ィエD1 and seィイD1375,385ィエD1 in a Bangladesh population. The presence of both seィイD1428ィエD1 (0.234) and seィイD1375,385ィエD1 (0.074) suggests the admixture of Aryans and Asians in Bangladesh. In addition, we found seィイD1fusィエD1 as one of null alleles in Japanese (0.05〜0.08) and the absence of the seィイD1fusィエD1 in Chinese, suggesting that the seィイD1fusィエD1 emerged from within Japanese.