Distribution of race-specific null alleles of the FUT2 in Africa, European and Asian populations.

FUT2 种族特异性无效等位基因在非洲、欧洲和亚洲人群中的分布。

• 批准号: 10041209
• 负责人: KIMURA Hiroshi
• 金额: $ 2.37万
• 依托单位: Dept. of Forensic Medicine, Kurume University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10041209/
• 关键词: ABO; secretor; FUT2; population; African; European; Asian; FUT3

The expression of ABO (H) antigens in secretions such as saliva is regulated by the Secretor gene (FUT2)-encoded α (1, 2) fucosyltransferase (Se enzyme). The ABO secretor group has at least one functional Se allele, and nonsecretors, who fail to express ABH antigens in saliva, are homozygous for the nonfunctional se allele. Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific. The null allele seィイD1428ィエD1 was found to be common in African (Xhosa) and Caucasians (European and Iranian), while the null allele seィイD1357,385ィエD1 was found to be common in Asian populations (Chinese, Korean, Japanese, Indonesian an Samoan). Frequency of seィイD1428ィエD1 and of seィイD1375,385ィエD1 in each population was 0.4〜0.5. However, we found both seィイD1428ィエD1 and seィイD1375,385ィエD1 in a Bangladesh population. The presence of both seィイD1428ィエD1 (0.234) and seィイD1375,385ィエD1 (0.074) suggests the admixture of Aryans and Asians in Bangladesh. In addition, we found seィイD1fusィエD1 as one of null alleles in Japanese (0.05〜0.08) and the absence of the seィイD1fusィエD1 in Chinese, suggesting that the seィイD1fusィエD1 emerged from within Japanese.

唾液等分泌物中 ABO (H) 抗原的表达受到分泌基因 (FUT2) 编码的 α (1, 2) 岩藻糖基转移酶（Se 酶）的调节。 ABO 分泌者群体至少有一个功能性 Se 等位基因，而不能在唾液中表达 ABH 抗原的非分泌者对于非功能性 se 等位基因是纯合的。我们对不同人群中 FUT2 的分子分析表明无效等位基因具有种族特异性。无效等位基因 seィイD1428ィエD1 在非洲（科萨人）和白种人（欧洲和伊朗）中很常见，而无效等位基因 seィイD1357,385ィエD1 在亚洲人群（中国人、韩国人、日本人、印度尼西亚人和萨摩亚人）中很常见。每个群体中seィイD1428ィエD1和seィイD1375,385ィエD1的频率为0.4〜0.5。然而，我们在孟加拉国人群中发现了 seiiD1428ィエD1 和 seィイD1375,385ィエD1。 seィイD1428ィエD1 (0.234) 和 seィイD1375,385ィエD1 (0.074) 的存在表明孟加拉国有雅利安人和亚洲人的混血。此外，我们发现seィイD1fusィエD1是日语中的无效等位基因之一（0.05〜0.08），而中文中没有seィイD1fusィエD1，这表明seィイD1fusィエD1来自日语内部。

项目成果

H. Pang, Y. Liu, Y. Koda, M. Soejima, JT. Jia, T. Schaphoff, ED. Du Toit, H. Kimura: "Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa."Hum Genet.. 102. 675-680 (1998)

H. Pang、Y. Liu、Y. Koda、M. Soejima、JT。

H. Pang, Y. Koda, M. Soejima, T. Schlaphoff, ED du Toit, H. Kimura: "Allelic diversity of the human plasma α(1,3)fucosyltransferase gene(FUT6)"Ann Hum Genet. 63. 277-284 (1999)

H. Pang、Y. Koda、M. Soejima、T. Schlaphoff、ED du Toit、H. Kimura：“人血浆 α(1,3) 岩藻糖基转移酶基因 (FUT6) 的等位基因多样性”Ann Hum Genet。 -284 (1999)

Koda Y, Soejima M, Kimura H.: "Structure and expression of H type GDP-L-fucose : β-D-galactoside2-α-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA." J Biol Chem. 272. 7501-7505

Koda Y、Soejima M、Kimura H.：“H 型 GDP-L-岩藻糖的结构和表达：β-D-半乳糖苷 2-α-L-岩藻糖基转移酶基因 (FUT1)。两个转录起始位点和选择性剪接产生多种形式的FUT1 mRNA。”《生物化学杂志》。272. 7501-7505

Pang H, Liu YH, Koda Y, Soejima M, Jia JT, Schlaphoff T, du Toit ED, Kimura H.: "Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa." Hum Genet. 102. 675-680 (1998)

Pang H、Liu YH、Koda Y、Soejima M、Jia JT、Schlaphoff T、du Toit ED、Kimura H.：“南非非洲（科萨）和高加索人群中 Lewis 基因 (FUT3) 的五种新错义突变。

Y.Liu,Y.Koda,M.Soejima,H.Pang,B.Wang,DS.Kim,HB.Oh,H.Kimura: "The fusion gene at the ABO-secretor locus (FUT2): absence in Chinese populations."J Hum Genet. 44. 181-184 (1999)

Y.Liu,Y.Koda,M.Soejima,H.Pang,B.Wang,DS.Kim,HB.Oh,H.Kimura：“ABO 分泌基因座融合基因 (FUT2)：中国人群中缺失