课题基金 / 基金详情

New MEG System for Improved Quantification of Human Brain Dynamics

New MEG System for Improved Quantification of Human Brain Dynamics
新的 MEG 系统可改善人脑动态的量化
批准号:
10430343
负责人:
Tony W Wilson
金额:
$192.47万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-15 至 2022-07-14

项目摘要

项目成果

Tony W Wilson的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结/文摘
英文摘要
Project Summary/Abstract The Omaha MEG site is one of the most productive, internationally-known MEG groups in the world. In 2018 alone, they published more than 20 peer-reviewed publications in top journals (e.g., Brain, Neurology), obtained numerous major NIH awards, and made high impact discoveries spanning multiple areas of human neuroscience. MEG, or magnetoencephalography, is an advanced method for noninvasively imaging population-level neurophysiological activity with high temporal (< 1ms) and spatial precision (2-3 mm). Application of the method has grown substantially over the past decade due to technical advancements and the growing interest in neural oscillations, dynamic connectivity, and other metrics where spatiotemporal precision is extremely important. The Omaha MEG group has had a major role in this growth and continues to lead the way in many areas of MEG research, often exceeding all other MEG sites on major measures of scientific productivity and impact. However, this group is now at a crossroads where their future growth, and even existence, is threatened by the helium shortage and the planned obsolesce of their current MEG instrument. Briefly, this instrument consumes over 100 L of liquid helium per week, which is not only very expensive but also increasingly difficult to obtain in the current era of helium shortages. The device could be retrofitted with a 70% efficient helium recycler, but that would be expensive and only a partial, temporary solution. Beyond this, their current device is almost 11 years old and the vendor will cease making replacement parts for their model at the end of 2019. Thus, even with helium, the device is nearing end of life. Given these concerns, we are proposing to replace our existing MEG system with a state-of-the-art Triux Neo MEG system from MEGIN (formerly Elekta). This new system is equipped with: (1) an almost 100% efficient helium recycling system, (2) advanced ARMOR sensors and electronics which significantly expand the system’s dynamic range and have lower intrinsic noise levels, (3) improved spatial precision, (4) a two-layer passively and actively shielded room with external environmental sensors, and (5) a new ergonomic design and fine positioning system to enhance patient comfort and ensure the most optimal head position relative to the array in each participant. Thus, this new system is a significant, major step forward for the Omaha MEG group and for the field as a whole, as the first Triux Neo installation was recently completed in the United States. With this device, the Omaha MEG group will continue to grow and attract the best new faculty and junior scientists, and will remain at the forefront of discovery in several major topic areas that are described in the proposal and of clear interest to the NIH and the translational neuroscience community.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Administrative Core
  • 批准号:
    10346724
  • 项目类别:
  • 资助金额:
    $81.66万
  • 财政年份:
    2022
  • 负责人:
    Tony W Wilson
  • 依托单位:
Center for Pediatric Brain Health
  • 批准号:
    10798920
  • 项目类别:
  • 资助金额:
    $25.0万
  • 财政年份:
    2022
  • 负责人:
    Tony W Wilson
  • 依托单位:
Administrative Core
  • 批准号:
    10580768
  • 项目类别:
  • 资助金额:
    $79.94万
  • 财政年份:
    2022
  • 负责人:
    Tony W Wilson
  • 依托单位:
Alteration and Renovation
  • 批准号:
    10346723
  • 项目类别:
  • 资助金额:
    $30.0万
  • 财政年份:
    2022
  • 负责人:
    Tony W Wilson
  • 依托单位:
国内基金
海外基金
M2巨噬细胞外泌体通过MEG3/PPARγ/Nrf2轴介导铁死亡抑制子痫前期进展的作用及机制研究
  • 批准号:
    2026JJ50641
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    喻玲
  • 依托单位:
H3K27me3–MEG3–MDM2/p53轴在髓母细胞瘤凋亡逃逸中作用机制的研究
  • 批准号:
    2026JJ81839
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    符星
  • 依托单位:
汉防己甲素诱导lncRNA MEG3 m6A甲基化修饰防治FSGS足细胞损伤的机制研究
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    余瑾
  • 依托单位:
桃红四物汤通过miR-107/DEPTOR/MEG3/VEGF路径促进骨折愈合的机制研究
  • 批准号:
    2025JJ70081
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    汤智
  • 依托单位: