Investigating the atomic structure of an immune cell inhibitory receptor
Investigating the atomic structure of an immune cell inhibitory receptor
批准号:
LP190101290
负责人:
Prof Jamie Rossjohn
金额:
$47.65万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2020
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2020-08-27 至 2023-12-31
中文摘要
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英文摘要
T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.
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