Investigating the atomic structure of an immune cell inhibitory receptor

研究免疫细胞抑制受体的原子结构

• 批准号: LP190101290
• 负责人: Prof Jamie Rossjohn
• 金额: $ 47.65万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-08-27 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190101290
• 关键词: Investigating; atomic; structure; immune; cell

T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.

T细胞在适应性免疫系统中起着关键作用，其反应性必须受到控制以防止异常反应。T细胞功能的中心是T细胞抗原受体，以及许多共刺激分子、共受体和抑制性受体。该提案与Immutep Ltd合作，旨在基本了解T细胞上发现的关键抑制性受体的结构和功能，称为淋巴细胞活化基因-3（LAG-3）。该提案利用细胞免疫学和结构生物学的组合来深入了解LAG-3分子的形式和功能。最终，这些基本知识可以被生物技术行业所利用。