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An investigation into CD1a, a versatile antigen-presenting molecule

An investigation into CD1a, a versatile antigen-presenting molecule
对多功能抗原呈递分子 CD1a 的研究
批准号：
DP220102402
负责人：
Prof Jamie Rossjohn
金额：
$41.34万
依托单位：
Monash University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2022
资助国家：
澳大利亚
项目状态：
未结题
起止时间：
2022-12-01 至 2025-11-30
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102402
关键词：
investigationintoCD1aversatileantigen

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中文摘要
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英文摘要
This project aims to investigate how T lymphocytes are activated by lipids presented by the skin-associated antigen-presenting molecule, CD1a. Using X-ray crystallography and cellular immunology, we will provide fundamental insight into this poorly understood immunological axis. We will determine the molecular basis for how CD1a presents diverse self and foreign lipids, and how such CD1a-lipid complexes are recognised by the responding T cells. This basic science discovery project will provide substantial new knowledge in the burgeoning field of lipid-mediated immunity, which should ultimately lead to new therapies targeting the CD1a lipid display molecule to either prevent immune mediated damage or promote protective immunity as required.
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