Exploring the immunomodulatory potential of Natural Killer T cells

探索自然杀伤 T 细胞的免疫调节潜力

• 批准号: LP140100920
• 负责人: Prof Jamie Rossjohn
• 金额: $ 41.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-12-31 至 2018-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100920
• 关键词: Exploring; immunomodulatory; potential; Natural; Killer

Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.

自然杀伤T细胞（NKT细胞）是一种先天性T细胞群，当与抗原呈递分子CD1d结合时，可识别一系列基于脂质的抗原。一旦被激活，NKT细胞迅速分泌多种细胞因子。该项目与Vaxine Pty Ltd合作，旨在获得对NKT识别脂质和脂质激活NKT细胞的基本了解。该项目旨在结合细胞免疫学和结构生物学来深入了解NKT细胞激动作用。