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An investigation into T cell immunity towards metabolites

An investigation into T cell immunity towards metabolites
T 细胞对代谢物免疫的研究
批准号：
DP220102401
负责人：
Prof Jamie Rossjohn
金额：
$52.22万
依托单位：
Monash University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2022
资助国家：
澳大利亚
项目状态：
未结题
起止时间：
2022-03-01 至 2025-02-28
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102401
关键词：
investigationintocellimmunitytowards

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英文摘要
This project aims to investigate how the immune system responds to small molecule metabolites, an emerging area in the life sciences about which little is known. The project aims to combine innovative mass spectrometry, structural and biochemical approaches to learn how metabolites are presented to specific T lymphocytes by an antigen presenting molecule called MR1. Outcomes are expected to transform the current understanding of the molecular basis underpinning metabolite-mediated immunity. Significant benefits are anticipated to include fundamental new knowledge about immunity that may ultimately be used by the biotechnology industry.
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    Monash University
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    Monash University
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