An investigation into T cell immunity towards metabolites

T 细胞对代谢物免疫的研究

• 批准号: DP220102401
• 负责人: Prof Jamie Rossjohn
• 金额: $ 52.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102401
• 关键词: investigation; into; cell; immunity; towards

This project aims to investigate how the immune system responds to small molecule metabolites, an emerging area in the life sciences about which little is known. The project aims to combine innovative mass spectrometry, structural and biochemical approaches to learn how metabolites are presented to specific T lymphocytes by an antigen presenting molecule called MR1. Outcomes are expected to transform the current understanding of the molecular basis underpinning metabolite-mediated immunity. Significant benefits are anticipated to include fundamental new knowledge about immunity that may ultimately be used by the biotechnology industry.

该项目旨在研究免疫系统如何对小分子代谢物做出反应，这是生命科学中一个鲜为人知的新兴领域。该项目旨在结合创新的质谱、结构和生化方法来了解代谢物如何通过称为 MR1 的抗原呈递分子呈递给特定的 T 淋巴细胞。预计结果将改变目前对代谢物介导免疫的分子基础的理解。预计显着的好处包括最终可能被生物技术行业使用的有关免疫的基本新知识。