Investigating the structure of a T cell immune checkpoint molecule

研究 T 细胞免疫检查点分子的结构

• 批准号: LP160101757
• 负责人: Prof Jamie Rossjohn
• 金额: $ 25.4万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-08-29 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101757
• 关键词: Investigating; structure; cell; immune; checkpoint

This project aims to investigate the basic structure and function of a key co-receptor expressed on T cells, known as lymphocyte activation gene-3. T cells play a role in the immune system but must be managed to prevent autoimmunity. Insight into the function of the lymphocyte activation gene-3 function can be used to tailor immunotherapeutics to treat a variety of diseases, including cancer. Functionality of the T cell receptor is determined by utilising structural biology and cellular immunology techniques. The impact of this project effects the development of innovative T cell immunomodulatory agents, improving the health and quality of life of the Australian population.

本项目旨在研究T细胞上表达的一个关键共受体的基本结构和功能，即淋巴细胞活化基因-3。T细胞在免疫系统中发挥作用，但必须设法防止自身免疫。对淋巴细胞活化基因-3功能的了解可以用于定制免疫疗法来治疗包括癌症在内的各种疾病。T细胞受体的功能是利用结构生物学和细胞免疫学技术确定的。该项目的影响影响了创新T细胞免疫调节剂的发展，改善了澳大利亚人口的健康和生活质量。