A structural and molecular investigation into the basic mechanism of T cell receptor complex function

T细胞受体复合物功能基本机制的结构和分子研究

• 批准号: DP140102487
• 负责人: Prof Jamie Rossjohn
• 金额: $ 45.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102487
• 关键词: structural; molecular; investigation; into; basic

Cellular fate is determined by interactions between membrane-bound receptors and their cognate ligands. The basic mechanism of how such receptor-mediated recognition events cause intracellular signalling is poorly understood in most biological systems, including the cellular immune recognition axis. This project will explore events central to cellular immunity by examining the interactions centred on T-cell receptor complexes. This project will explore the molecular mechanisms underpinning these key receptor-recognition events and relate these observations to T-cell activation. The proposal will shed fundamental insight into Major Histocompatibility Complex restriction, T-cell development and how antigen recognition leads to T-cell signal transduction.

细胞命运由膜结合受体与其同源配体之间的相互作用决定。这种受体介导的识别事件如何引起细胞内信号传导的基本机制在大多数生物系统中知之甚少，包括细胞免疫识别轴。该项目将通过研究以T细胞受体复合物为中心的相互作用来探索细胞免疫的核心事件。该项目将探索这些关键受体识别事件的分子机制，并将这些观察结果与T细胞活化联系起来。该提案将揭示主要组织相容性复合物限制，T细胞发育以及抗原识别如何导致T细胞信号转导的基本见解。