BONE LOSS WITH AGE--EPIDEMIOLOGY, FAMILIAL AND CROSS-CULTURAL CONSIDERATIONS

随年龄增长的骨质流失——流行病学、家族和跨文化因素

• 批准号: 3745424
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745424
• 关键词: Bosnia-Hercegovina; Central America; European; Japan; Pacific Islands; aging; biomechanics; bone density; bone fracture; culture; family genetics; femur fracture; hormone regulation /control mechanism; human old age (65+); human population genetics; human subject; laboratory rat; osteoporosis; physiologic bone resorption

During the fourth decade of life, the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. Menopause and the associated estrogen deficiency will enhance bone loss in females. It has also been suspected that bone loss is familial, mainly because of the increased prevalence of osteoporosis in relatives, although there are no satisfactory scientific data to support either a familial or a genetic control of bone loss. In long bones, cortical bone is resorbed from the endosteal surface. Because of the thinning of the cortical bone shell, bones lose their mechanical integrity and fracture more readily. The trabecular bone mass of the vertebral column also decreases with age. Vertebral compression fractures and fractures of the femoral neck are the most serious consequences of bone loss. This project deals with the epidemiological, genetic, cross-sectional, longitudinal, and biomechanical aspects of bone loss (1) among the participants of the Baltimore Longitudinal Study of Aging (BLSA), (2) in genetic isolates of the Adriatic Sea Islands of Croatia and the island of Guam in Micronesia, Japan, Central America, Albania and other parts of the world (cross-cultural), (3) in rats.

在生命的第四个十年，人类骨骼开始失去骨骼。