STUDY OF NORMAL HUMAN VARIABILITY AND CROSS CULTURAL AGING

正常人类变异性和跨文化衰老的研究

• 批准号: 3802183
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802183
• 关键词: Alzheimer's disease; World Health Organization; aging; amyotrophic lateral sclerosis; breast neoplasms; cerebral dominance; cooperative study; degenerative motor system disease; disease /disorder proneness /risk; ethnic group; genetic disorder; genetic markers; human genetic material tag; human population genetics; human subject; linkage mapping; neoplasm /cancer genetics

This project represents an ongoing collaborative effort, involving WHO and other national and international laboratories to coordinate the collection, evaluation and interpretation of normal genetic markers in order to study the cross-cultural patterns of genetic and extraneous factors as they relate to normative aging and to diseases with late onset, including Alzheimer's disease, breast cancer, Amyotrophic Lateral Sclerosis, and Parkinsonism Dementia. Specifically, the objectives of this study are: A) To study the cross cultural patterns of genetic and non-genetic factors in an effort to better understand the process of normative aging. B) To study the genetic segregation of these markers in families with late onset diseases, such as Alzheimer's disease, breast cancer, ALS and others, in an effort to establish genetic linkages and eventual identification of the factors responsible for these diseases. C) To study the distribution of dermatoglyphics, lateral dominance and other genetic variables in BLSA participants and other control samples, as well as in patients with late onset diseases.

该项目是一项持续的合作努力，世卫组织和 其他国家和国际实验室协调收集， 评估和解释正常的遗传标记，以研究 遗传和外来因素的跨文化模式， 与正常衰老和迟发性疾病有关，包括 阿尔茨海默氏病、乳腺癌、肌萎缩侧索硬化症和 帕金森症痴呆症。 具体而言，本研究的目标是：A） 研究遗传和非遗传因素的跨文化模式， 努力更好地理解正常老化的过程。 B）学习 这些标记在晚发型家系中的遗传分离 疾病，如阿尔茨海默病，乳腺癌，ALS和其他，在一个 努力建立遗传联系，并最终确定 导致这些疾病的因素。 （一）研究分布情况 BLSA中的皮纹、侧优势和其他遗传变量 参与者和其他对照样本，以及晚期 发病