EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

关岛 ALS/PD 综合征的流行病学和遗传学研究

• 批准号: 3802186
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802186
• 关键词: Pacific Islands; aging; bone density; disease /disorder proneness /risk; epidemiology; genetic markers; human subject; immobilization of body part; longitudinal human study; paralysis; parents; patient /disease registry; population genetics; siblings

Lateral Sclerosis (ALS) and Parkinsonism (PD) on the island of Guam. A patient-control prospective study (Registry) was established in 1958. The initial analysis of the Registry data published in 1967 and the follow up analysis published in 1986 showed that these diseases as found on Guam are highly familial. That is, relatives of patients have a higher risk for developing the disease than those of controls. The next question to be answered is whether this familial occurrence is due to genetic or environmental factors. The specific objectives of this study are: A) To ascertain the extent of genetic involvement in the high incidence of Amyotrophic Lateral Sclerosis and Parkinsonism Dementia through: (1) segregation analysis of the pedigrees of all patient diagnosed since 1958 and, (2) through segregation analysis of sibships where both parents, one parent or neither of the parents (controls) are affected with ALS and PD. B) To study the distribution of various established genetic and anthropological markers among the normal Guamanian populations and compare them with those of the ALS and PD patients. C) to ascertain the effects of immobilization due to paralysis on bone density.

侧索硬化症（ALS）和帕金森症（PD）在关岛。 一 病人对照前瞻性研究（Registry）建立于1958年。 的 1967年发表的登记数据的初步分析和后续行动 1986年发表的分析表明，在关岛发现的这些疾病是 高度家族化。 也就是说，患者的亲属有更高的风险， 比对照组更易患病。 下一个问题是 答案是这种家族性事件是否是由于遗传或 环境因素 本研究的具体目标是：A） 确定遗传参与高发病率的程度， 肌萎缩侧索硬化症和帕金森氏症痴呆症通过：（1） 1958年以来确诊病例家系分离分析 （2）通过对双亲、一方和另一方的兄弟姐妹关系的分离分析， 父母或父母中的任何一方（对照）都不受ALS和PD的影响。 B）研究各种已建立的遗传和 人类学标记之间的正常关岛人口和比较 他们与ALS和PD患者的情况相同。 （三）确定影响 由于瘫痪而导致的固定对骨密度的影响。