STUDY OF NORMAL HUMAN VARIABILITY AND CROSS CULTURAL AGING

正常人类变异性和跨文化衰老的研究

• 批准号: 3821406
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821406
• 关键词: World Health Organization; aging; body physical characteristic; cerebral dominance; classification; diagnostic tests; genetic disorder; genetic markers; health surveys; human age group; human population genetics; human subject; interview; longitudinal human study; population survey; southeast Asian

This project represents an ongoing collaborative effort, involving WHO and other national and international laboratories to coordinate the collection, evaluation and interpretation of normal genetic markers, in order to, study the cross-cultural patterns of genetic and extraneous factors as they relate to normative aging and to diseases with late onset. Specifically, the objectives of this study are: A) To study the distribution of DNA minisatellites, dermatoglyphics, lateral dominance and other genetic variables in BLSA participants and other control samples, as well as in patients with late onset diseases. B) To study the genetic segregation of these markers in families with late onset diseases, such as Alzheimer's disease, breast cancer, ALS and others, in an effort to establish genetic linkages and eventual identification of the factors responsible for these diseases and C) To study the cross cultural patterns of genetic and non genetic factors in an effort to better understand the process of normative aging.

该项目是一项持续的合作努力， 世卫组织和其他国家和国际实验室， 协调收集、评估和解释正常的 遗传标记，以研究跨文化模式， 与正常衰老相关的遗传和外部因素 和迟发性疾病。 具体而言， 本研究的主要内容是：（1）研究DNA小卫星的分布， 皮纹学、侧向优势和其他遗传变量 BLSA参与者和其他对照样本，以及 迟发性疾病患者。 B）研究基因 这些标记物在迟发性疾病家族中的分离， 如阿尔茨海默氏病、乳腺癌、肌萎缩侧索硬化症等， 努力建立遗传联系，并最终确定 导致这些疾病的因素和C）研究 遗传和非遗传因素的跨文化模式 努力更好地理解正常老化的过程。