BONE LOSS WITH AGE--EPIDEMIOLOGY, FAMILIAL AND CROSS-CULTURAL CONSIDERATIONS

随年龄增长的骨质流失——流行病学、家族和跨文化因素

• 批准号: 5200263
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5200263
• 关键词: Bosnia-Hercegovina; Central America; European; Japan; Pacific Islands; aging; biomechanics; bone density; culture; epidemiology; family genetics; human old age (65+); human subject; interview; laboratory rat; longitudinal human study; osteoporosis

After the third decade of life the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. Endosteal cortical and trabecular bone is lost from both the axial and the peripheral sites of the skeleton. Menopause and the associated estrogen deficiency will enhance bone loss in females. It has also been suspected that bone loss is familial, mainly because of the increased prevalence of osteoporosis in relatives, although there are no satisfactory scientific data to support a genetic control of bone loss. While age-related bone loss does not usually interfere with the normal function of the individual, occasionally it will produce considerable thinning of the cortical bone shell, causing bones to lose their integrity and fracture more readily. Decreases in the trabecular bone would result to vertebral compression of fractures and fractures of the femoral neck. This project investigates the epidemiological, genetic, cross-sectional, longitudinal and cross-cultural aspects of bone loss among participants of the BLSA, and among genetic isolates from Europe, Japan, Australasia, Central America and Africa.

在生命的第三个十年后，人类的骨骼开始失去骨骼。 也就是说，骨量相对于骨量减少。 骨内膜 皮质骨和松质骨从中轴骨和 骨骼的外围部位 更年期和相关的雌激素 缺乏会增加女性的骨质流失。 也有人怀疑 骨质流失是家族性的，主要是因为 骨质疏松症的亲属，虽然没有令人满意的 科学数据来支持遗传控制骨质流失。 而 年龄相关的骨质流失通常不会干扰正常功能 有时候，它会产生相当大的稀疏， 皮质骨外壳，导致骨骼失去完整性， 更容易骨折。 骨小梁的减少会导致 脊椎压缩骨折和股骨颈骨折。 该项目调查了流行病学、遗传学、横截面、 参与者中骨丢失的纵向和跨文化方面 BLSA，以及来自欧洲，日本，澳大拉西亚， 中美洲和非洲。