EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

关岛 ALS/PD 综合征的流行病学和遗传学研究

• 批准号: 3817553
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817553
• 关键词: Asians; aging; bone density; degenerative motor system disease; disease /disorder proneness /risk; epidemiology; genetic markers; genetic registry /resource /referral center; human subject; immobilization of body part; interview; longitudinal human study; paralysis; parent offspring interaction; patient /disease registry; population genetics; southeast Asia

This project represents further efforts to elucidate the etiology of high incidence of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism Dementia (PD) on the island of Guam. A patient- control prospective study (Registry) was established in 1958. The objective of the registry has been to determine (1) whether relatives of ALS and PD patients have higher risk for developing the disease than relatives of controls and (2) if familial occurrence does exist, to determine the extent of genetic involvement in the etiology of the disease. A twenty-five year follow-up analysis of the registry has been concluded and the results were published. The registries are now being maintained for future follow-up studies. Other objectives of this study are: 1) to investigate the genetic and epidemiological factors contributing to the very high incidence of Amyotrophic Lateral Sclerosis and Parkinsonism Dementia (ALS/PD) on Guam; 2) to evaluate the distribution of the various established genetic and anthropological markers among the normal Guamanian population and compare them with those of the ALS/PD patients; and 3) to ascertain the effects of immobilization due to paralysis on bone density.

该项目代表了进一步努力阐明病因 肌萎缩侧索硬化症（ALS）的高发病率， 帕金森痴呆症（PD）在关岛。 一个病人- 对照前瞻性研究（Registry）建立于1958年。 的 登记处的目标是确定（1）是否 ALS和PD患者的亲属有更高的风险发展为 与对照组的亲属相比，（2）如果是家族性的， 存在，以确定遗传的程度 参与疾病的病因学。 二十五年 对登记册的后续分析已经结束， 结果已公布。 登记册现在由 以便将来进行后续研究。 本研究的其他目的是：1）调查遗传 和流行病学因素造成的非常高的发病率 肌萎缩侧索硬化症和帕金森痴呆症（ALS/PD） （2）评估各种已建立的机构的分布情况; 遗传学和人类学标记在正常的关岛人中 并将其与ALS/PD患者进行比较;以及 3)为了确定由于瘫痪而导致的固定对 骨密度