EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

关岛 ALS/PD 综合征的流行病学和遗传学研究

• 批准号: 3767751
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767751
• 关键词: Asians; Japanese; Pacific Islands; Parkinson's disease; amyotrophic lateral sclerosis; chromosome movement; disease /disorder proneness /risk; epidemiology; genetic disorder; genetic disorder diagnosis; genetic models; human population genetics; human subject

Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism dementia (PD) are neurological degenerative disorders that occur in three high incidence foci in the western Pacific: among the Chamorros of Guam and the northern Mariana islands, among the Japanese on the Kii peninsula and among the Auyu and Jakai peoples of West New Guinea. Eventhough, clinically ALS and PD as seen on Guam are two distinct disorders, preliminary analyses indicated that combining all three diagnoses (ALS, PD, and ALS+PD) into one affected diagnosis for genetic analyses, was reasonable. An Age, sex and birth cohort-specific liability was defined and segregation analysis was performed under both logistic and normal models for this liability at the time of disease onset. Under either model, purely environmental, Mendelian dominant and Mendelian recessive hypotheses could be rejected, but a two allele additive major locus hypothesis could not be rejected.

肌萎缩性侧索硬化症（ALS）和帕金森性痴呆（PD）