EPIDEMIOLOGICAL AND GENETIC STUDIES OF ALS/PD COMPLEX OF GUAM

为了阐明该病高发的原因， 肌萎缩侧索硬化症与帕金森病痴呆 关岛(PD)：一项患者对照前瞻性研究 (登记处)成立于1958年。注册处包括： 除了患者和他们各自匹配的对照组外， 他们各自的父母、兄弟姐妹、后代和配偶。这个 登记处的目标是确定(1)是否 ALS和PD患者的亲属患上ALS和PD的风险更高 疾病比对照的亲属和(2)是否有家族史 发生的情况确实存在，以确定遗传的程度 与疾病的病因学有关。二十五年 刚刚完成了对登记册的后续分析， 结果会被公布。 这项研究的其他目的是：1)研究遗传 和流行病学因素导致了很高的 肌萎缩侧索硬化症和帕金森病的发病率 在关岛的痴呆(ALS/PD)；2)评估 各种已建立的遗传和人类学标记 并将其与正常的关岛人群进行比较 对ALS/PD患者的影响；以及3)确定 瘫痪所致的制动对骨密度影响。

In an effort to elucidate the etiology of high incidence of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism Dementia (PD) on the island of Guam, a patient-control prospective study (Registry) was established in 1958. The Registry includes, in addition to the patients and their individually matched controls, their respective parents, sibs, offspring and spouses. The objective of the registry has been to determine (1) whether relatives of ALS and PD patients have higher risk for developing the disease than relatives of controls and (2) if familial occurrence does exist, to determine the extent of genetic involvement in the etiology of the disease. A twenty-five year follow-up analysis of the registry has just been concluded and the results are published. Other objectives of this study are: 1) to investigate the genetic and epidemiological factors contributing to the very high incidence of Amyotrophic Lateral Sclerosis and Parkinsonism Dementia (ALS/PD) on Guam; 2) to evaluate the distribution of the various established genetic and anthropological markers among the normal Guamanian population and compare them with those of the ALS/PD patients; and 3) to ascertain the effects of immobilization due to paralysis on bone density.