BONE LOSS WITH AGE--EPIDEMIOLOGY, FAMILIAL AND CROSS-CULTURAL CONSIDERATIONS

随年龄增长的骨质流失——流行病学、家族和跨文化因素

• 批准号: 3789738
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789738
• 关键词: Asians; Bosnia-Hercegovina; European; Pacific Islands; aerobic exercise; aging; biomechanics; bone density; culture; dogs; epidemiology; family genetics; human old age (65+); human population genetics; human subject; laboratory rat; longitudinal human study; physiologic bone resorption

During the fourth decade of life, the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. Menopause and the associated estrogen deficiency will enhance bone loss in females. It has also been suspected that bone loss is familial, mainly because of the increased prevalence of osteoporosis in relatives, although there are no satisfactory scientific data to support either a familial or a genetic control of bone loss. In long bones, cortical bone is resorbed from the endosteal surface. Because of the thinning of the cortical bone shell, bones lose their mechanical integrity and fracture more readily. The trabecular bone mass of the vertebral column also decreases with age. The vertebral plates decrease in density, lose resistance to vertical compression stress and become more vulnerable to vertebral collapse. Vertebral compression fractures and fractures of the femoral neck are the most serious consequences of bone loss. This project deals with the epidemiological, genetic, cross-sectional, longitudinal, and biomechanical aspects of bone loss (1) among the participants of the Baltimore Longitudinal Study of Aging (BLSA), (2) in genetic isolates of the Adriatic Sea Islands of Croatia and the island of Guam in Micronesia, (3) senior athlete population, (4) in long distance runners and relatively inactive normal controls, and (5) in rats and dogs.

在生命的第四个十年，人类骨骼开始失去骨骼。 也就是说，骨量相对于骨量减少。 更年期和 相关的雌激素缺乏会增加女性的骨质流失。 它有 也有人怀疑骨质流失是家族性的，主要是因为 亲属中骨质疏松症的患病率增加，尽管没有 令人满意的科学数据，以支持无论是家庭或遗传 控制骨质流失。 在长骨中，皮质骨从骨中吸收， 骨内膜面 由于皮质骨外壳变薄， 骨骼失去其机械完整性并更容易断裂。 的 脊柱的骨小梁质量也随着年龄的增长而减少。 的 椎板密度降低，丧失垂直阻力 压缩应力，并变得更容易脊椎塌陷。 脊椎压缩性骨折和股骨颈骨折是常见的骨折类型。 最严重的后果是骨质流失。 本项目涉及 流行病学、遗传学、横截面、纵向和生物力学 巴尔的摩参与者的骨质流失方面（1） 老化的纵向研究（BLSA），（2）在亚得里亚海的遗传分离株 克罗地亚海群岛和密克罗尼西亚关岛，（3）高级 运动员人口，（4）在长距离运动员和相对不活跃 正常对照组;（5）大鼠和犬。