INVESTIGATIONS OF OSTEOARTHRITIS AND BONE LOSS

骨关节炎和骨质流失的研究

• 批准号: 4687866
• 负责人: C C PLATO
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687866
• 关键词: X ray; adolescence (12-20); aging; blood chemistry; bone density; bone fracture; bone metabolism; bone metabolism disorder; calcitonin; calcium; child (0-11); epidemiology; exercise; gender difference; health surveys; hormones; human population genetics; human subject; immobilization of body part; longitudinal human study; magnesium; musculoskeletal disorder diagnosis; musculoskeletal injury; osteoarthritis; osteoporosis; parathyroid hormones; pathologic bone resorption; phosphorus; radiography; vitamin D

Osteoarthritis and bone loss are the two principal age related changes of the human skeleton. Even though these changes are considered inherent to aging, they may result in incapacitating ailments. Bone loss and osteoarthritis are universal phenomena. The advanced cases of osteoarthritis (degenerative joint disease) produce severe restrictions of movement associated with pain. Advance bone loss may result in osteoporosis and frequent bone fractures. At some time during the fourth decade of life the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. In tabular bones, bone is resorbed from the endossteal surface. Because of the thinning of the cortical bone shell, bones lose their mechanical integrity and fracture more readily. The trabecular bone mass of the verteral column also decreases with age. The vertebral plates decrease in density, lose resistance to vertical compression stress and are more vulnerable to vertebral collapse. Most prominent are vertebral compression fractures and fractures of the femoral neck. The following skeletal sites are involved in the present study: hand-wrist, ulna and radius and vertebral column. This project deals with the epidemiological, genetic and longitudinal aspects of osteoarthritis and bone loss among (1) the participants of the Baltimore Longitudinal Study, (2) in a sample of normal children and adult Guamanians (Chamorros), (3) among patients afflicted with Amyotrohpic Lateral Sclerosis/Parkinsonism Dementia Complex of Guam, and (4) study of bone mineral density and effect of muscular activity on bone in rats.

骨关节炎和骨丢失是两个主要的年龄相关的变化， 人类的骨架 尽管这些变化被认为是固有的， 老化，他们可能会导致丧失能力的疾病。 骨丢失和 骨关节炎是普遍现象。 先进案例 骨关节炎（退行性关节疾病）产生严重的限制， 与疼痛相关的运动。 晚期骨质流失可能导致 骨质疏松症和频繁骨折。 在第四次世界大战期间 十年的生命，人类的骨骼开始失去骨骼。 也就是说， 与骨体积有关。 在板状骨中， 从骨内膜表面。 因为皮质骨变薄 贝壳，骨头失去了它们的机械完整性，更容易断裂。 脊柱骨小梁骨量也随年龄增长而减少。 椎板密度降低，失去垂直阻力 压缩应力，更容易发生椎骨塌陷。 最 突出的是椎骨压缩性骨折和股骨骨折 脖子 本研究涉及以下骨骼部位： 手腕、尺骨、桡骨和脊柱。 本项目涉及 骨关节炎的流行病学、遗传学和纵向方面， （1）巴尔的摩纵向研究的参与者中的骨质流失， (2)在正常儿童和成年关岛人（查莫罗人）的样本中，（3） 在患有肌萎缩侧索硬化症/帕金森综合征的患者中， 关岛痴呆综合征，（4）骨密度和影响的研究 肌肉活动对骨骼的影响。