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REGIONAL CEREBRAL CIRCULATION AND METABOLISM

REGIONAL CEREBRAL CIRCULATION AND METABOLISM
区域脑循环和代谢
批准号：
3968463
负责人：
L SOKOLOFF
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968463
关键词：
adenosinetriphosphatase adrenergic agents aging amphetamines animal old age auditory pathways autoradiography bioenergetics blood brain barrier brain circulation brain mapping brain metabolism computed axial tomography deoxyglucose diagnosis quality /standard glucose metabolism ions mathematical model mature animal mental disorder diagnosis morphine neuroanatomy neurochemistry neuropharmacology newborn animals phentolamine propranolol psychotomimetic drug radionuclide diagnosis radiotracer visual pathways

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中文摘要
翻译
本文提出了一种定量测定反应速率的方法
英文摘要
A method has been developed for the quantitative determination of the rates of local glucose consumption in the discrete functional and structural components of the brain in conscious or anesthetized laboratory animals. The method is based on the use of (14C)deoxyglucose as a tracer for glucose flux through the hexokinase step. Local [14C]deoxyglucose-6-phosphate concentrations in the tissues of the CNS are measured by a quantitative autoradiographic method. In as much as the autoradiographs of the relative rates of local glucose consumption can be used directly for metabolic mapping of functionally linked structures in the CNS, the method is being used to study alterations in the energy metabolism of the discrete functional and structural components of the brain in a variety of physiological, pharmacological, and pathological states.
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