课题基金 / 基金详情

REGIONAL CEREBRAL CIRCULATION AND METABOLISM

REGIONAL CEREBRAL CIRCULATION AND METABOLISM
区域脑循环和代谢
批准号：
3944659
负责人：
L SOKOLOFF
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3944659
关键词：
aging animal old age autoradiography bioenergetics brain circulation brain mapping brain metabolism deoxyglucose diagnosis quality /standard glucose metabolism mature animal morphine neuroanatomy newborn animals positron emission tomography radionuclide diagnosis radiotracer

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中文摘要
翻译
脱氧葡萄糖的定量测定方法
英文摘要
The deoxyglucose method for the quantitative determination of rates of local glucose consumption in the discrete functional and structural components of the brain of conscious or anesthetized laboratory animals was developed in this laboratory over 10 years ago. In this method (14C)deoxyglucose is employed as a tracer for glucose flux through the hexokinase step; the product, (14C)deoxyglucose-6-phosphate, is measured by quantitative autoradiography. The method continues to be used to study alterations in local energy metabolism in a variety of physiological, pharmacological and a limited number of pathological states. Its suitability to a wider range of pathologic conditions is being extended and special time constraints which may be present in the method's adaptation for use in human subjects with (18C)fluorodeoxyglucose and PET have been examined.
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会议论文
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