REGIONAL CEREBRAL CIRCULATION AND METABOLISM

区域脑循环和代谢

• 批准号: 6162839
• 负责人: L SOKOLOFF
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162839
• 关键词: Animalia; antipyrine; brain metabolism; deoxyglucose; glucose metabolism; magnetic resonance imaging; method development; positron emission tomography; radiotracer

This is an omnibus project that covers a number of studies on development, validation, refinement, and applications of methods for measuring physiological and biochemical processes in functional and structural units of the nervous system in vivo in animals and man. The [14C]iodoantipyrine) method for measuring local cerebral blood flow and the [14C]deoxyglucose method for measuring local cerebral glucose utilization are examples of methods previously developed in this project for use in animals and which were subsequently adapted for use in man with PET and H215O and 18FDG, respectively. We are now applying these methods to determine the basic chemical and physiological mechanisms that mediate the functional activations of brain blood flow and metabolism that are now so extensively used to study cognitive and other functions as well as to models of normal and abnormal conditions of brain function (i.e., hypoglycemia, glucoprivation, chronic bromide intoxication., etc.). During this last year we initiated studies to adapt the radioactive deoxyglucose method for use with MRI spectroscopy which, if successful, would obviate the need for blood sampling and the use of radioisotopes.

这是一个综合性的项目，涵盖了许多关于 方法的开发、验证、改进和应用 测量生理和生化过程中的功能和 动物和人类体内神经系统的结构单位。这个 [14C]测量局部脑血流量的方法和 [~(14)C]脱氧葡萄糖法测定局部脑葡萄糖 利用是本项目中以前开发的方法的例子 用于动物，并随后被改造用于人类 分别用PET、H_215O和18FDG。我们现在正在应用这些 确定其基本化学和生理机制的方法 调节脑血流量的功能激活和 新陈代谢现在被如此广泛地用于研究认知和其他 函数以及正常和非正常情况的模型 脑功能(即低血糖、葡萄糖代谢、慢性溴化物 醉酒等)。在过去的一年里，我们启动了研究，以 将放射性脱氧葡萄糖方法与核磁共振波谱结合使用 如果成功，将不再需要采血和 放射性同位素的使用。