REGIONAL CEREBRAL CIRCULATION AND METABOLISM

脱氧葡萄糖法定量测定血药浓度 局部葡萄糖消耗量在离散泛函和 清醒或麻醉状态下大脑的结构成分 这个实验室发展了10多年的实验动物。 那是以前的事了。在这种方法(14C)中，脱氧葡萄糖被用作示踪剂 通过己糖激酶步骤的葡萄糖通量；该产品， (14C)脱氧葡萄糖-6-磷酸，通过定量测定 放射自显影。这种方法将继续被用于研究 多种疾病患者局部能量代谢的改变 生理、药理和数量有限的病理 各州。它对更广泛的病理条件的适应性 以及可能存在的特殊时间限制 在该方法适用于人类受试者时， (18C)氟脱氧葡萄糖和正电子发射计算机断层扫描(PET)。

The deoxyglucose method for the quantitative determination of rates of local glucose consumption in the discrete functional and structural components of the brain of conscious or anesthetized laboratory animals was developed in this laboratory over 10 years ago. In this method (14C)deoxyglucose is employed as a tracer for glucose flux through the hexokinase step; the product, (14C)deoxyglucose-6-phosphate, is measured by quantitative autoradiography. The method continues to be used to study alterations in local energy metabolism in a variety of physiological, pharmacological and a limited number of pathological states. Its suitability to a wider range of pathologic conditions is being extended and special time constraints which may be present in the method's adaptation for use in human subjects with (18C)fluorodeoxyglucose and PET have been examined.