REGIONAL CEREBRAL CIRCULATION AND METABOLISM

区域脑循环和代谢

• 批准号: 3859847
• 负责人: L SOKOLOFF
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859847
• 关键词: Mammalia; brain disorder diagnosis; brain metabolism; deoxyglucose; diagnosis design /evaluation; glucose metabolism; glucose transport; neurochemistry; neuropharmacology; neurophysiology; positron emission tomography; radionuclide diagnosis; radionuclide double label; radiotracer

This project is part of a long term program of research directed at the development, validation, and applications of methods for measurement of local rates of physiological and biochemical processes in discrete functional and structural components of the brain. These methods are designed to be used in conscious laboratory animals and in some cases eventually adapted for use in man with PET. The [14C]iodoantipyrine method for measuring local cerebral blood flow and the [14C]deoxyglucose ([14C]DG) method for measuring local cerebral glucose utilization are examples of outcomes of this research program. It is noteworthy that the only standard and accepted quantitative methods that are routinely used in man with PET are derivatives of these two methods. Recent work on this project has included applications of these methods to studies of various physiological, biochemical, and pharmacological states, and pathological states. Efforts during this past year have been directed mainly toward these goals: 1) development of applicability of the DG method to severe pathological states when the values of these parameters may deviate from those in physiological states; 2) development of a sequential double label procedure with which to study control and altered behavioral states in the same animal.

该项目是一项长期研究计划的一部分， 发展、验证和应用测量方法， 生理和生化过程的局部速率 大脑的功能和结构组成部分。 这些方法 设计用于有意识的实验室动物， 最终适用于人体PET。 [14 C]碘安替比林法 用于测量局部脑血流量和[14 C]脱氧葡萄糖（[14 C]DG） 用于测量局部脑葡萄糖利用的方法是 这个研究项目的成果。 值得注意的是， 以及常规用于PET检查的公认定量方法 是这两种方法的衍生物。 该项目最近的工作 包括这些方法在各种生理学研究中的应用， 生物化学和药理学状态以及病理状态。 努力 在过去的一年里，主要是为了实现这些目标：1） 发展DG方法对严重病理状态的适用性 当这些参数的值可能偏离生理参数时， 2）开发一种连续的双标记程序， 在同一只动物中研究控制和改变的行为状态。