Muscle resilience across the life course: from cells to society

整个生命过程中的肌肉弹性：从细胞到社会

• 批准号: BB/W018284/1
• 负责人: Peter Smith
• 金额: $ 37.41万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW018284%2F1
• 关键词: Muscle; resilience; across; life; course

The number of people living into old age is increasing rapidly throughout the world, however although people live longer, they are not healthier. Adults in the UK now spend the last decade of life in poor health, placing a large burden on health and social care services. One of the big changes in our bodies as we age is the loss of muscle tissue, with up to 50% of muscle mass being lost by 80 years of age. Muscle is an important tissue in our body, as it is vital for movement, posture and the way in which food is used as energy. The loss of muscle during ageing makes it harder to carry out day-to-day activities, increases frailty and the risk of falls and injuries, and increases the risk of conditions like heart disease, diabetes and dementia. Muscle loss is the single largest reason for losing independence in old age, so it is important to keep our muscles healthy (resilient) as we grow older, by eating well and leading an active lifestyle.When muscles age, several things happen: muscle fibres become smaller and fewer in number, the muscle contains more fat and fibrous tissue, and the ability of muscle tissue to repair and renew itself decreases. Not everyone ages in the same way - in fact there is a great deal of variation when we look at large numbers of older people. Some of the differences between people can be explained by the genes an individual inherits. Much of the remaining variation is due to a person's life circumstances. Factors like how much exercise we take, the food we eat, our educational background and whether we live comfortably or in poverty all play a major role. Although scientists around the world have worked hard to understand the causes of muscle ageing, it is such a complex problem that we need to find new ways to tackle it. In the past, researchers have tended to focus on one part of the problem, in an area where they are expert. We plan to take a new approach that shifts away from studying single systems on their own and move towards a combined effort where we study muscle ageing across all scales from the microscopic level to the scale of populations. We will also join forces with researchers from other disciplines like mathematics, artificial intelligence, social sciences and geography to find new approaches to solving the big questions in muscle ageing. The aim of this network is to bring together researchers, businesses and the people and organisations that benefit from research, from many areas, offering new insights into muscle health and an understanding of the pathways leading to muscle ageing. Specifically we will:Develop a national network of researchers across a wide range of disciplines to focused on muscle resilience and ageing throughout life and across scales.Increase the understanding of the mechanisms influencing muscle ageing and the variability between individuals. Provide secondments and training for early career scientists and technical staff.Work with policy makers, health care practitioners, industry and patient groups to translate our insights into improved health benefits, developing new preventative and treatment strategiesThe outcomes of our network activities will be wide ranging, spanning from new scientific insights, the application of new technologies, interdisciplinary grant proposals, to training and exchange of knowledge across disciplines, to helping make policy at the national level, with the unified aim of relieving the major societal problems connected to muscle ageing and loss of mobility.

全世界进入老年的人数正在迅速增加，然而，尽管人们寿命更长，但他们并不健康。英国的成年人现在在生命的最后十年中健康状况不佳，给健康和社会保健服务带来了沉重的负担。随着年龄的增长，我们身体的一个重大变化是肌肉组织的损失，到80岁时，肌肉质量损失高达50%。肌肉是我们身体中的重要组织，因为它对运动，姿势和食物作为能量的使用方式至关重要。随着年龄的增长，肌肉的流失会使人们更难进行日常活动，增加虚弱和福尔斯和受伤的风险，并增加心脏病、糖尿病和痴呆症等疾病的风险。肌肉萎缩是老年人失去独立性的最大原因，因此，随着年龄的增长，通过良好的饮食和积极的生活方式来保持我们的肌肉健康（弹性）是很重要的。当肌肉老化时，会发生几件事：肌肉纤维变得更小，数量更少，肌肉含有更多的脂肪和纤维组织，肌肉组织修复和更新自身的能力下降。并不是每个人都以同样的方式变老--事实上，当我们观察大量的老年人时，会发现有很大的差异。人与人之间的一些差异可以用个体遗传的基因来解释。剩下的大部分变化是由于一个人的生活环境。我们锻炼的程度、我们吃的食物、我们的教育背景以及我们生活是否舒适或贫困等因素都发挥着重要作用。尽管世界各地的科学家都在努力了解肌肉老化的原因，但这是一个非常复杂的问题，我们需要找到新的方法来解决它。在过去，研究人员往往专注于问题的一部分，在他们擅长的领域。我们计划采取一种新的方法，从单独研究单个系统转向共同努力，从微观水平到人口规模，研究所有尺度的肌肉老化。我们还将与数学、人工智能、社会科学和地理学等其他学科的研究人员合作，寻找解决肌肉老化问题的新方法。该网络的目的是汇集研究人员，企业以及从许多领域的研究中受益的人员和组织，为肌肉健康提供新的见解，并了解导致肌肉衰老的途径。具体来说，我们将：发展一个跨学科的全国性研究人员网络，专注于终身和跨尺度的肌肉弹性和衰老。增加对影响肌肉衰老的机制和个体之间的差异的理解。为早期职业科学家和技术人员提供借调和培训。与政策制定者，医疗保健从业人员，行业和患者团体合作，将我们的见解转化为改善健康的益处，开发新的预防和治疗策略我们的网络活动的成果将是广泛的，从新的科学见解，新技术的应用，跨学科的资助提案，培训和跨学科的知识交流，帮助制定国家一级的政策，统一的目标是缓解与肌肉老化和丧失流动性有关的重大社会问题。

项目成果

Activity Behaviors in British 6-Year-Olds: Cross-Sectional Associations and Longitudinal Change During the School Transition.

• DOI: 10.1123/jpah.2021-0718
• 发表时间: 2022-08-01
• 期刊: Journal of physical activity & health
• 影响因子: 3.1
• 作者: Hesketh KR;Brage S;Inskip HM;Crozier SR;Godfrey KM;Harvey NC;Cooper C;Van Sluijs EMF
• 通讯作者: Van Sluijs EMF

DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.

• DOI: 10.1186/s13395-023-00326-y
• 发表时间: 2023-10-28
• 期刊: Skeletal muscle
• 影响因子: 4.9

Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).

• DOI: 10.1002/jcsm.12876
• 发表时间: 2022-03
• 期刊: Journal of cachexia, sarcopenia and muscle
• 作者: Antoun E;Garratt ES;Taddei A;Burton MA;Barton SJ;Titcombe P;Westbury LD;Baczynska A;Migliavacca E;Feige JN;Sydall HE;Dennison E;Dodds R;Roberts HC;Richardson P;Sayer AA;Shaw S;Cooper C;Holbrook JD;Patel HP;Godfrey KM;Lillycrop KA;EpiGen Global Research Consortium
• 通讯作者: EpiGen Global Research Consortium

Family-focused contextual factors associated with lifestyle patterns in young children from two mother-offspring cohorts: GUSTO and EDEN.

• DOI: 10.1186/s12966-022-01266-4
• 发表时间: 2022-03-15
• 期刊: The international journal of behavioral nutrition and physical activity
• 作者: Chia A;Descarpentrie A;Cheong RN;Toh JY;Natarajan P;Sugianto R;Cai S;Saldanha-Gomes C;Dargent-Molina P;de Lauzon-Guillain B;Plancoulaine S;Lança C;Saw SM;Godfrey KM;Shek LP;Tan KH;Charles MA;Chong YS;Heude B;Eriksson JG;Müller-Riemenschneider F;Lioret S;Chong MF;Bernard JY
• 通讯作者: Bernard JY

Early Nutrition and Long-Term Health

早期营养和长期健康

• DOI: 10.1016/b978-0-12-824389-3.00017-9
• 发表时间: 2022
• 作者: Burton M