THE VP6 GENE OF EQUINE ROTAVIRUS STRAIN H-2 ENCODES TWO VP6 PROTEINS

马轮状病毒H-2株的VP6基因编码两种VP6蛋白

• 批准号: 3814282
• 负责人: M GORZIGLIA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3814282
• 关键词: Rotavirus; conformation; genetic mapping; genetic strain; genetic translation; horses; mutant; nucleic acid sequence; virus antigen; virus genetics; virus protein

Until now every rotavirus VP6 gene which has been characterized was shown to contain a unique AUG located 23 nucleotides downstream of its 5' terminus. An exception to this rule was recently observed. The VP6 gene of the equine H-2 rotavirus strain contains an additional AUG at residues 132-134, which initiates the translation of a second VP6 protein. Both VP6 products assume a trimeric conformation in the mature virion. The VP6 gene of the H2 strain is the second example of the presence of an active second AUG codon in rotavirus. The first example was previously described by others in the VP7 gene.

到目前为止，已鉴定的轮状病毒VP 6基因都是 含有位于其5'端下游23个核苷酸的独特AUG， 终点站最近发现了这一规则的一个例外。VP 6基因 马H-2轮状病毒株在残基处含有额外的AUG 132-134，其启动第二个VP 6蛋白的翻译。两个VP 6 产物在成熟病毒体中呈现三聚体构象。vp 6基因 H2菌株的第二个例子是存在活性第二个 轮状病毒中的AUG密码子。第一个例子之前由 VP 7基因中的其他基因。