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THE VP6 GENE OF EQUINE ROTAVIRUS STRAIN H-2 ENCODES TWO VP6 PROTEINS

THE VP6 GENE OF EQUINE ROTAVIRUS STRAIN H-2 ENCODES TWO VP6 PROTEINS
马轮状病毒H-2株的VP6基因编码两种VP6蛋白
批准号：
3814282
负责人：
M GORZIGLIA
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3814282
关键词：
Rotavirus conformation genetic mapping genetic strain genetic translation horses mutant nucleic acid sequence virus antigen virus genetics virus protein

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英文摘要
Until now every rotavirus VP6 gene which has been characterized was shown to contain a unique AUG located 23 nucleotides downstream of its 5' terminus. An exception to this rule was recently observed. The VP6 gene of the equine H-2 rotavirus strain contains an additional AUG at residues 132-134, which initiates the translation of a second VP6 protein. Both VP6 products assume a trimeric conformation in the mature virion. The VP6 gene of the H2 strain is the second example of the presence of an active second AUG codon in rotavirus. The first example was previously described by others in the VP7 gene.
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