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EXPERIMENTAL STUDIES OF VARIOUS ROTAVIRUSES AND THEIR REASSORTANTS IN ANIMALS

EXPERIMENTAL STUDIES OF VARIOUS ROTAVIRUSES AND THEIR REASSORTANTS IN ANIMALS
多种轮状病毒及其重配体的动物实验研究
批准号：
3809622
负责人：
Y HOSHINO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809622
关键词：
Rotavirus antibody neutralization test diarrhea disease /disorder model gene expression germ free condition immunological substance rotavirus vaccines serology /serodiagnosis serotyping swine viral vaccines virulence virus classification virus envelope virus genetics virus infection mechanism virus protein virus replication

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英文摘要
Continued efforts have been made to delineate the genetic mechanisms underlying virulence of rotavirus in the newborn gnotobiotic piglet model. In addition to the gene encoding rotavirus outer capsid protein VP4 or VP7, the tenth gene appears to play an independent role in determining the virulence of rotavirus in the porcine model. Elucidation of the constellation of genes required for rotavirus virulence may have important implications for the development of effective rotavirus vaccine strategies.
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CHARACTERIZATION OF ROTAVIRUSES FROM ASYMPTOMATIC HUMAN NEONATAL INFECTIONS
ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES
GENETIC STUDIES OF ROTAVIRUS PATHOGENESIS
COLD-ADAPATION OF HUMAN ROTAVIRUSES