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COLD-ADAPATION OF HUMAN ROTAVIRUSES

COLD-ADAPATION OF HUMAN ROTAVIRUSES
人类轮状病毒的冷适应
批准号：
5200522
负责人：
Y HOSHINO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5200522
关键词：
Rotavirus attenuated microorganism gene mutation live vaccine rotavirus vaccines temperature sensitive mutant tissue /cell culture virus genetics

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中文摘要
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英文摘要
The selection of cold-adapted mutants of selected human rotaviruses of major epidemiologic importance was reported last year. These mutants included strain D (VP4:1A; VP7:1), DS-1 (VP4:1B; VP7:2), Wa x DS-1 (VP4:1A; VP7:2), and Wa x P (VP4:1A; VP7:3). Selected mutant vaccines are currently under clinical evaluation. In an attempt to provide antigenic coverage for each of the four epidemiologically important VP7 serotypes (G1, G2, G3, and G4), we passaged a Wa x ST3 (VP4:1A ; VP7:4) reassortant serially in primary African green monkey kidney cells at progressively lower suboptimal temperature (30 degrees C, 28 degrees C, and 26 degrees C). Triple plaque purification of each mutant selected after tenth serial passages is in progress at the temperature of that passage series.
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