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COLD ADAPTATION OF HUMAN ROTAVIRUSES

COLD ADAPTATION OF HUMAN ROTAVIRUSES
人类轮状病毒的冷适应
批准号：
3790840
负责人：
Y HOSHINO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3790840
关键词：
Cercopithecidae Rotavirus cold temperature genetic strain kidney cell microorganism culture phenotype rotavirus vaccines temperature sensitive mutant tissue /cell culture virus characteristic virus genetics virus replication

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中文摘要
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英文摘要
Two human rotavirus cell-culture isolates (strains D [VP4:1A; VP7:1], and DS-1 [VP4:1B; VP7:2]) as well as two human x human rotavirus reassortants (Wa x P [VP4:1A; VP7:3] and Wa x DA-1 [VP4:1A; VP7:2]) have been successfully adapted to grow in primary African Green Monkey kidney cells at the suboptimal temperature of 30oC, 28oC, or 26oC. These rotavirus strains were cold-adapted to determine whether cold-adapted (ca) mutants selected by this strategy are attenuated and suitable for use in a live virus vaccine. The 26oC and 28oC ca mutants of the D, DS-1, Wa x P, and Wa x DS-1 viruses have been plaque-purified and their phenotypes have been characterized.
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CHARACTERIZATION OF ROTAVIRUSES FROM ASYMPTOMATIC HUMAN NEONATAL INFECTIONS
ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES
GENETIC STUDIES OF ROTAVIRUS PATHOGENESIS
COLD-ADAPATION OF HUMAN ROTAVIRUSES
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