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ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES

ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES
人和动物轮状病毒的分离和血清型特征
批准号：
3960553
负责人：
Y HOSHINO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3960553
关键词：
Reoviridae disease Rotavirus acute infectious nonbacterial gastroenteritis antibody neutralization test gene mutation genetic manipulation genetic recombination genetic strain immunogenetics kidney cell microorganism hemagglutinin microorganism immunology serotyping tissue /cell culture viral vaccines virus antigen virus classification virus genetics

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中文摘要
翻译
本发明公开了一种天然存在的型间猪轮状病毒株SB-1A， 基因和血清学分析。 结果表明，该分离物是 基于其VP 7的血清型4和基于其VP 3的血清型5。 通过分析 单VP 3基因置换的抑制剂，我们证实VP 3是作为 有效诱导中和抗体如VP 7。 第四个基因组 猪轮状病毒SB-1A株和OSU株及犬轮状病毒片段 菌株CU-1显示编码病毒血凝素。 人轮状病毒株WI-61被发现血清型不同于 四种已知的人类血清型
英文摘要
A naturally occurring intertypic porcine rotavirus strain SB-1A was analyzed genetically and serologically. It was shown that this isolate was serotype 4 based on its VP7 and serotype 5 based on its VP3. By analyzing single VP3 gene substitution reassortants, we confirmed that VP3 was as potent in inducing neutralizing antibodies as VP7. The fourth genome segment of porcine rotavirus strains SB-1A and OSU and canine rotavirus strain CU-1 was shown to code for viral hemagglutinin. Human rotavirus strain WI-61 was found to be distinct serotypically from the four known human serotypes.
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会议论文
CHARACTERIZATION OF ROTAVIRUSES FROM ASYMPTOMATIC HUMAN NEONATAL INFECTIONS
ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES
GENETIC STUDIES OF ROTAVIRUS PATHOGENESIS
COLD-ADAPATION OF HUMAN ROTAVIRUSES
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