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EXPERIMENTAL STUDIES IN ANIMALS WITH VARIOUS ROTAVIRUSES AND THEIR REASSORTANTS

EXPERIMENTAL STUDIES IN ANIMALS WITH VARIOUS ROTAVIRUSES AND THEIR REASSORTANTS
各种轮状病毒及其重配体的动物实验研究
批准号：
3818195
负责人：
Y HOSHINO
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818195
关键词：
Reoviridae disease Rotavirus active immunization antibody formation antibody neutralization test antiviral antibody complement fixation tests cross immunity diarrhea disease /disorder model enzyme linked immunosorbent assay gene mutation genetic recombination genetic strain germ free condition hemagglutination test immunogenetics immunological substance infant animal serology /serodiagnosis serotyping swine viral vaccines virulence virus antigen virus classification virus cytopathogenic effect virus genetics virus infection mechanism virus protein

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中文摘要
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英文摘要
Continued efforts have been made to delineate the genetic mechanisms underlying pathogenicity of rotavirus in the newborn gnotobiotic piglet model. In these studies the VP3 and VP7 genes have been shown to play an important independent role in rotavirus growth in the gut and in induction of diarrhea. In addition, to these two outer capsid- encoding genes an additional gene (or genes) has been shown to be required for the induction of diarrhea. These findings may have implications for the development of effective reassortant rotavirus vaccines.
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会议论文
CHARACTERIZATION OF ROTAVIRUSES FROM ASYMPTOMATIC HUMAN NEONATAL INFECTIONS
ISOLATION AND SEROTYPIC CHARACTERIZATION OF HUMAN AND ANIMAL ROTAVIRUSES
GENETIC STUDIES OF ROTAVIRUS PATHOGENESIS
COLD-ADAPATION OF HUMAN ROTAVIRUSES
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