MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

胸腺源性 (T) 抑制细胞和增强细胞的作用方式

• 批准号: 3809557
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3809557
• 关键词: Salmonella typhimurium; Streptococcus pneumoniae; T lymphocyte; antibody formation; bacterial antigens; bacterial polysaccharides; delayed hypersensitivity; dextrans; helper T lymphocyte; immunoglobulin G; immunoglobulin M; immunomodulators; laboratory mouse; leukocyte activation /transformation; lipids; microorganism immunology; passive immunization; suppressor T lymphocyte; thymus

Direct evidence was obtained to indicate that the magnitude of the antibody response of mice to bacterial (Leuconostoc) dextran B1355 is influenced in a negative and positive manner by the action of suppressor T cells (Ts) and amplifier T cells (TA), respectively. Thus, the antibody response to this well-defined antigen can be added to the growing list of other microbial polysaccharide antigens, e.g., Type Ill pneumococcal polysaccharide (SSS-III), Neisseria meningitidis group A and C capsular polysaccharides, Pseudomonas aeruginosa lipopolysaccharide, Streptococcus mutans polysaccharide, and Serratia marcesans lipopolysaccharide, whose antibody responses are known to be influenced by regulatory T cells (Ts and TA). Evidence was obtained to indicate that populations of these regulatory T cells expand in a clonal manner in response to immune B cells and that such expansion is facilitated by IL-2.

获得的直接证据表明， 小鼠对细菌（明串珠菌）葡聚糖B1355的反应受到影响 通过抑制性T细胞（Ts）的作用的阴性和阳性方式， 放大器T细胞（TA）。因此，抗体对此的反应 一种定义明确的抗原可以被添加到不断增长的其他微生物 多糖抗原，例如，III型肺炎球菌多糖 （SSS-III），脑膜炎奈瑟氏菌A和C组荚膜多糖， 铜绿假单胞菌脂多糖、变形链球菌 多糖和粘质沙雷氏菌脂多糖，其抗体 已知应答受调节性T细胞（Ts和TA）的影响。 获得的证据表明，这些调节性T细胞的群体 细胞响应免疫B细胞以克隆方式扩增， IL-2促进了扩增。