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MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS
胸腺源性 (T) 抑制细胞和增强细胞的作用方式
批准号：
3768733
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768733
关键词：
Pseudomonas aeruginosa acyl group bactericidal immunity chemical structure immunoregulation leukocyte activation /transformation lipopolysaccharides suppressor T lymphocyte thymus virulence

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中文摘要
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英文摘要
Treatment with lipid A or monophosphoryl lipid A abolishes the expression of suppressor T cell (Ts) function, without adversely influencing the expression of other T cell activity. This is due to the number and location of fatty acyl groups present, as well as to fatty acyl chain length. The inability of the lipid A of Pseudomonas aeruginosa to abolish Ts function, in conjunction with the capacity of inner-core region polysaccharides of its lipopolysaccharide to stimulate Ts activity suggest an important virulence mechanism.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
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