MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

胸腺源性 (T) 抑制细胞和增强细胞的作用方式

• 批准号: 4688365
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4688365
• 关键词: B lymphocyte; Streptococcus pneumoniae; affinity chromatography; antibody formation; antibody specificity; bacterial antigens; bacterial genetics; bacterial polysaccharides; cell transformation; cyclophosphamide; helper T lymphocyte; hybrid cells; hybridomas; immune tolerance /unresponsiveness; immunogenetics; immunoglobulin genes; immunoregulation; membrane activity; microorganism immunology; monoclonal antibody; suppressor T lymphocyte

The transfer of bone marrow-derived precursors of antibody-forming cells (B cells) from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess of an enzyme (polysaccharide depolymerase) capable of hydrolyzing SSS-III, does not alter the capacity of these cells to activate regulatory T cells. These findings indicate that the activation of regulatory T cells by immune B cells is not mediated by residual antigen on the surface of transferred cells.

抗体形成细胞（B）的骨髓来源前体的转移 细胞）的免疫小鼠 （SSS-III）导致抑制性和放大性T细胞的活化 控制受体小鼠中抗体反应的大小， 随后用SSS-III免疫。 转移B的既往治疗 具有过量的酶（多糖解聚酶）的细胞能够 水解SSS-III，不会改变这些细胞激活 调节性T细胞 这些发现表明， 免疫B细胞介导的调节性T细胞不受 转移细胞的表面。