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MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS
胸腺源性 (T) 抑制细胞和增强细胞的作用方式
批准号：
4688365
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4688365
关键词：
B lymphocyte Streptococcus pneumoniae affinity chromatography antibody formation antibody specificity bacterial antigens bacterial genetics bacterial polysaccharides cell transformation cyclophosphamide helper T lymphocyte hybrid cells hybridomas immune tolerance /unresponsiveness immunogenetics immunoglobulin genes immunoregulation membrane activity microorganism immunology monoclonal antibody suppressor T lymphocyte

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中文摘要
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英文摘要
The transfer of bone marrow-derived precursors of antibody-forming cells (B cells) from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess of an enzyme (polysaccharide depolymerase) capable of hydrolyzing SSS-III, does not alter the capacity of these cells to activate regulatory T cells. These findings indicate that the activation of regulatory T cells by immune B cells is not mediated by residual antigen on the surface of transferred cells.
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会议论文
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
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