REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

几种细菌对IgM抗体应答的调节 脂多糖，包括大肠杆菌0113脂多糖(EC 0113-脂多糖)， 大肠埃希菌055脂多糖(EC 055-脂多糖)和粘质沙雷氏菌脂多糖(SM-内毒素) 检查过了。对EC 0113-LPS的记忆是在暴露于单个 这种抗原的亚免疫原性剂量；它以循环的方式发展和 持续了至少20天。相比之下，注射了AFP的小鼠 EC 055脂多糖或SM-脂多糖亚免疫原剂量对小鼠免疫功能的抑制作用 而不是记忆对相同的内毒素的自体反应 启动；这种抑制的发展是剂量和时间依赖的 而不是由于免疫球蛋白同种类型的转换。细胞机制 参与记忆的表达和对内毒素的抑制 详细调查了。其他研究的结果表明， 脂多糖多克隆刺激导致细胞优先激活 记忆，而不是原始的B细胞。

Regulation of IgM antibody responses to several bacterial lipopolysaccharides, including Escherichia coli 0113 LPS (EC 0113-LPS), E.coli 055 LPS (EC 055-LPS) and Serratia marcesans LPS (SM-LPS) was examined. Memory to EC 0113-LPS was generated after exposure to a single subimmunogenic dose of this antigen; it developed in a cyclic manner and persisted for at least 20 days. By contrast, mice primed with a subimmunogenic dose of EC 055 LPS or SM-LPS developed profound suppression rather than memory for the antobody response to the same LPS used for priming; the development of such suppression was dose and time dependent and not due to a switch in immunoglobulin isotype. The cellular mechanisms involved in the expression of memory and suppression to LPS are being investigated in detail. The results of other studies showed that polyclonal stimulation by LPS results in the preferential activation of memory, rather than virgin B cells.