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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
对微生物抗原的抗体反应的遗传控制
批准号：
3821966
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3821966
关键词：
B lymphocyte active immunization antibody formation antibody specificity antigen antibody reaction bacterial genetics bacterial polysaccharides exotoxins genetic regulation genetic strain immune tolerance /unresponsiveness immunogenetics immunologic memory immunosuppressive antileukocyte serum leukocyte activation /transformation lipopolysaccharides microorganism antigen microorganism immunology

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中文摘要
翻译
C3H/HEN(对Lipid-A和C3H/HeJ有反应)(对 类脂A)用绵羊红细胞启动，以产生 显著的免疫记忆力。当这些老鼠 随后用细菌脂多糖(LPS)治疗， 仅注意到记忆细胞的显著多克隆激活 在C3H/HEN小鼠体内。这表明，脂类A的部分 脂多糖分子在记忆激活中的重要作用 B细胞。
英文摘要
C3H/HeN (responsive to Lipid-A and C3H/HeJ (not responsive to Lipid A) were primed with sheep erythrocytes so as to generate significant immunological memory. When these mice were treated subsequently with bacterial lipopolysaccharide (LPS), significant polyclonal activation of memory cells was noted only in C3H/HeN mice. This suggest that the Lipid A moiety of the LPS molecule plays an important role in the activation of memory B cells.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
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