GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS

对微生物抗原的抗体反应的遗传控制

• 批准号: 3960449
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3960449
• 关键词: B lymphocyte; Escherichia coli; Streptococcus pneumoniae; active immunization; antibody formation; antibody specificity; bacterial genetics; bacterial polysaccharides; exotoxins; gene complementation; genetic markers; genetic recombination; genetic regulation; genetic strain; immune tolerance /unresponsiveness; immunogenetics; immunosuppressive antileukocyte serum; leukocyte activation /transformation; linkage mapping; microorganism antigen; microorganism immunology

Immune B cells from various strains of inbred mice activate suppressor T cells after transfer to recipients of the same strain. However, this does not occur using immune B cells obtained from either young or old NZB/N mice, even though suppressor T cells can be activated in situo upon priming with a low dose of antigen. This suggests major differences between NZB/N and other strains of mice in either the homing patterns for immune B cells or the manner in which suppressor T cells are activated. The expression of amplifier and helper T cell activity was examined in NZB/N mice of different ages. Loss of suppressor T cell activity and increased amplifier T cell activity coincided with the development of autoimmune disease in aging NZE/N mice,. Helper T cell activity was present in young NZB/N mice; however, it was absent in old NZB/N mice expressing maximal amplifier T cell activity. This provides additional support for the fact that amplifier and helper functions are mediated by different subpopulations of T cells.

不同品系近交系小鼠免疫B细胞激活抑制性T细胞 细胞转移到同一品系的受体后。 但这并 使用从年轻或老年NZ B/N获得的免疫B细胞不会发生 小鼠，即使抑制性T细胞可以在引发后原位激活， 低剂量的抗原 这表明NZB/N之间的主要差异 和其他品系的小鼠在免疫B细胞的归巢模式中 或者抑制性T细胞被激活的方式。 的表达 在NZB/N小鼠中检测了放大器和辅助性T细胞活性， 不同年龄 抑制性T细胞活性丧失和放大器增加 T细胞活性与自身免疫性疾病的发展一致， 衰老的NZE/N小鼠。 辅助T细胞活性存在于年轻的NZB/N小鼠中; 然而，在表达最大放大器T的老年NZB/N小鼠中， 细胞活性 这为以下事实提供了额外的支持： 放大器和辅助功能是由不同的亚群介导的 T细胞。