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REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
微生物多糖抗原抗体反应的调节
批准号：
3818115
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818115
关键词：
B lymphocyte Salmonella typhimurium Streptococcus pneumoniae active immunization antibody formation antigen antibody reaction bacterial antigens bacterial polysaccharides helper T lymphocyte immune tolerance /unresponsiveness immunoglobulin genes immunoregulation laboratory mouse lipopolysaccharides microorganism immunology suppressor T lymphocyte

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中文摘要
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英文摘要
Treatment with non-toxic monophosphoryl lipid A (MPL), derived from a polysaccharide deficient heptoseless Re-mutant of Salmonella typhimurium was found to inactivate suppressor T cell activity as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the magnitude of the antibody response to Type III pneumococcal polysaccharide (SSS- III). The effect produced, which could not be attributed to the polyclonal activation of immune B cells by MPL, were dependent upon the dose of MPL used, as well as the time when MPL was given relative to low-dose priming or immunization with SSS-III. Neither amplifier nor helper T cell activity was decreased by treatment with the same--or larger--doses of MPL.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
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