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REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
微生物多糖抗原抗体反应的调节
批准号：
3818115
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818115
关键词：
B lymphocyte Salmonella typhimurium Streptococcus pneumoniae active immunization antibody formation antigen antibody reaction bacterial antigens bacterial polysaccharides helper T lymphocyte immune tolerance /unresponsiveness immunoglobulin genes immunoregulation laboratory mouse lipopolysaccharides microorganism immunology suppressor T lymphocyte

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中文摘要
翻译
使用无毒的单磷脂A(MPL)治疗，来源为 沙门氏菌多糖缺乏型再突变株 鼠伤寒沙门氏菌被发现可以灭活抑制T细胞的活性，因为 小剂量免疫接种程度的下降证明了这一点 表现为瘫痪，并增加了 对III型肺炎球菌多糖(SSS-)的抗体应答 三)。所产生的影响，这不能归因于 MPL对免疫B细胞的多克隆激活依赖于 使用MPL的剂量以及给予MPL的时间 相对于低剂量引爆或SSS-III免疫。都不是 治疗后放大NOR辅助T细胞活性降低 使用相同或更大剂量的MPL。
英文摘要
Treatment with non-toxic monophosphoryl lipid A (MPL), derived from a polysaccharide deficient heptoseless Re-mutant of Salmonella typhimurium was found to inactivate suppressor T cell activity as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the magnitude of the antibody response to Type III pneumococcal polysaccharide (SSS- III). The effect produced, which could not be attributed to the polyclonal activation of immune B cells by MPL, were dependent upon the dose of MPL used, as well as the time when MPL was given relative to low-dose priming or immunization with SSS-III. Neither amplifier nor helper T cell activity was decreased by treatment with the same--or larger--doses of MPL.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
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