IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES

本项目的目的是阐明 调节丝虫病和非丝虫病状态下的免疫应答。 免疫调节研究已经检查了抗原特异性免疫应答的现象。 微丝蚴血症患者的无反应性，通过显示这种无反应性是 寄生虫抗原增殖细胞的频率降低， 抗增殖细胞因子IL-10和TGF-β的产生。 已经开发了用于主要细胞因子的过滤免疫斑测定法 并用来证明在人类感染蠕虫时， Th 2 CD 4+细胞的扩增。这些基因的表型特征 TH 2 CD 4+细胞显示其为CD 45 RO + HLA-DR+ CD 27-。底层 对某些寄生虫抗原的免疫应答的遗传基础是 目前正在研究。

The purpose of this project is to delineate the mechanisms involved in regulating immune response in filarial and nonfilarial disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of a diminished frequency of proliferating cells to parasite antigen and of the production of the antiproliferative cytokines, IL-10 and TGF-beta. Filter immunoplaque assays for the major cytokines have been developed and used to demonstrate that in helminth infections of humans there is an expansion of Th2 CD4+ cells. The phenotypic characterization of these TH2 CD4+ cells has shown them to be CD45RO+ HLA-DR+ CD27-. The underlying genetic basis for the immune responses to certain parasite antigens is currently being studied.