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IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES

IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
丝虫病和非丝虫病的免疫调节和免疫识别
批准号：
3768747
负责人：
T B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768747
关键词：
Filarioidae anergy cytokine filariasis helminthiasis helper T lymphocyte immunity immunogenetics immunoregulation microorganism immunology plaque assay transforming growth factors

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中文摘要
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英文摘要
The purpose of this project is to delineate the mechanisms involved in regulating immune response in filarial and nonfilarial disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of a diminished frequency of proliferating cells to parasite antigen and of the production of the antiproliferative cytokines, IL-10 and TGF-beta. Filter immunoplaque assays for the major cytokines have been developed and used to demonstrate that in helminth infections of humans there is an expansion of Th2 CD4+ cells. The phenotypic characterization of these TH2 CD4+ cells has shown them to be CD45RO+ HLA-DR+ CD27-. The underlying genetic basis for the immune responses to certain parasite antigens is currently being studied.
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MOLECULAR DEFINITION OF FILARIAL ANTIGENS
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
MOLECULAR DEFINITION OF FILARIAL ANTIGENS
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