课题基金 / 基金详情

IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES

IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
丝虫病和非丝虫病的免疫调节和免疫识别
批准号：
3803110
负责人：
T B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3803110
关键词：
B lymphocyte Filarioidae T lymphocyte antibody formation antigen antibody reaction antimicroorganism antibody biological signal transduction filariasis helminthic antigen human subject immunoglobulin E immunoglobulin G immunoregulation leukocyte activation /transformation lymphokines microorganism immunology monoclonal antibody neutralizing antibody onchocerciasis tissue /cell culture

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中文摘要
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英文摘要
The purpose of this project is to delineate the mechanisms involved in regulating the humoral and cellular responses in patients with filariasis and other disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of a diminished frequency of proliferating cells to parasite antigen. In vitro models of parasite-antigen driven antibody production along with recombinant lymphokines and neutralizing antibodies have been used to understand the signals necessary to regulate antibody production in response to parasite antigen at a molecular level.
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MOLECULAR DEFINITION OF FILARIAL ANTIGENS
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES